Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. (Q39700543)

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3 February 2020

title

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2 (English)

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0 references

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9

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Tattym E. Shaikenov

3

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David M. Sabatini

10

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author name string

Delphine Boulbes

1

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3 February 2020

Chien-Hung Chen

2

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Nitin K Agarwal

4

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Timothy R Peterson

5

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Terri A Addona

6

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Hasmik Keshishian

7

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Steven A Carr

8

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Dos D Sarbassov

11

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publication date

25 May 2010

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Molecular Cancer Research

3 February 2020

published in

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volume

8

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issue

6

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page(s)

896-906

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Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

3 February 2020

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

14 September 2017

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

14 September 2017

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

14 September 2017

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14 September 2017

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

14 September 2017

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

14 September 2017

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

14 September 2017

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Growing roles for the mTOR pathway

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K-ras as a target for cancer therapy

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

14 September 2017

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Activation of AKT kinases in cancer: implications for therapeutic targeting

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

14 September 2017

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mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

14 September 2017

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Rictor is a novel target of p70 S6 kinase-1.

14 September 2017

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Rapamycin regulates the phosphorylation of rictor

14 September 2017

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TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

14 September 2017

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Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

20 August 2018

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Ras activation in human breast cancer

20 August 2018

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10.1158/1541-7786.MCR-09-0409

20 August 2018

Identifiers

DOI

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3 February 2020

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3 February 2020

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