Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. (Q39677752)

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scientific article published on 20 July 2010

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English	Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer.	scientific article published on 20 July 2010

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8 February 2020

Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer (English)

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Rajni B. Sharma

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Anirban Maitra

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author name string

Savita Bisht

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Masamichi Mizuma

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Georg Feldmann

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Niki A Ottenhof

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Dipankar Pramanik

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Venugopal Chenna

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Collins Karikari

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Michael G Goggins

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Michelle A Rudek

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Rajani Ravi

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Amarnath Maitra

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publication date

20 July 2010

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Molecular Cancer Therapeutics

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8 February 2020

2255-2264

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8 February 2020

Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo

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Systemic delivery of curcumin: 21st century solutions for an ancient conundrum

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

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14 September 2017

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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Phase II trial of curcumin in patients with advanced pancreatic cancer

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Potential of spice-derived phytochemicals for cancer prevention.

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Curcumin and cancer: an "old-age" disease with an "age-old" solution

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14 September 2017

Pancreatic cancer.

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Bioavailability of curcumin: problems and promises

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Role of curcumin in cancer therapy

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Nab-paclitaxel for breast cancer: a new formulation with an improved safety profile and greater efficacy

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Curcumin: the Indian solid gold

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14 September 2017

Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy

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High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin

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Chemopreventive and therapeutic effects of curcumin

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14 September 2017

Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning

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Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer

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Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

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Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved

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Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions

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Characterization and cytotoxicity of self-organized assemblies of curcumin and amphiphatic poly(ethylene glycol).

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Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy.

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Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy

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14 September 2017

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

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Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells

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Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

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Curcumin differentially sensitizes malignant glioma cells to TRAIL/Apo2L-mediated apoptosis through activation of procaspases and release of cytochrome c from mitochondria.

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Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

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Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells

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Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

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The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

1 reference

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12 December 2020

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Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway

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https://pubmed.ncbi.nlm.nih.gov/20647339

12 December 2020

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Identifiers

10.1158/1535-7163.MCT-10-0172

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8 February 2020

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8 February 2020

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Europe PubMed Central

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8 February 2020

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