Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors (Q42441080)

31 October 2017

title

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors (English)

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31 October 2017

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https://api.crossref.org/works/10.1038/SJ.ONC.1206388

1 January 2024

9

Gordon B Mills

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31 October 2017

Roberto Bianco

1

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31 October 2017

Incheol Shin

2

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31 October 2017

Andrea Basso

5

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31 October 2017

Neal Rosen

6

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31 October 2017

Junji Tsurutani

7

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31 October 2017

Christoph A. Ritter

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12743604

1 January 2024

F. Michael Yakes

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12743604

1 January 2024

Phillip A. Dennis

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12743604

1 January 2024

Carlos L. Arteaga

10

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1 January 2024

publication date

1 May 2003

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31 October 2017

8 May 2003

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12743604

https://www.nature.com/articles/1206388.pdf

1 January 2024

language of work or name

English

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work available at URL

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https://api.crossref.org/works/10.1038/SJ.ONC.1206388

https://www.nature.com/articles/1206388

1 January 2024

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https://api.crossref.org/works/10.1038/SJ.ONC.1206388

1 January 2024

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31 October 2017

volume

22

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31 October 2017

issue

18

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31 October 2017

page(s)

2812-2822

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 October 2017

cites work

1 reference

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Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types.

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

21 January 2018

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

21 January 2018

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Cellular survival: a play in three Akts

21 January 2018

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

21 January 2018

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Anti-epidermal growth factor receptor antibodies inhibit the autocrine-stimulated growth of MDA-468 human breast cancer cells

21 January 2018

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Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members

21 January 2018

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Mutation analysis of the PTEN/MMAC1 gene in lung cancer

21 January 2018

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Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?

21 January 2018

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Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

21 January 2018

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ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth

21 January 2018

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Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers

21 January 2018

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Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

21 January 2018

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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

21 January 2018

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Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice

21 January 2018

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

21 January 2018

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Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)

21 January 2018

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

21 January 2018

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Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition

21 January 2018

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The ErbB signaling network: receptor heterodimerization in development and cancer

21 January 2018

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Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

21 January 2018

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The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification

21 January 2018

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ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial

21 January 2018

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

21 January 2018

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PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

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Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

21 January 2018

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

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PTEN: life as a tumor suppressor

21 January 2018

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

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AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

21 January 2018

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Untangling the ErbB signalling network

21 January 2018

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Role of the insulin-like growth factor family in cancer development and progression

21 January 2018

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

21 January 2018

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 January 2024

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1 January 2024

Identifiers

1 reference

Dimensions Publication ID

31 October 2017

1004564925

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1 reference