Antitumour and antiangiogenic effects of Aplidin in the 5TMM syngeneic models of multiple myeloma (Q39638460)

13 September 2017

Antitumour and antiangiogenic effects of Aplidin in the 5TMM syngeneic models of multiple myeloma (English)

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13 September 2017

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angiogenesis inhibitor

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J Caers

1

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13 September 2017

E Menu

2

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13 September 2017

H De Raeve

3

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13 September 2017

D Lepage

4

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13 September 2017

E Van Valckenborgh

5

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13 September 2017

B Van Camp

6

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13 September 2017

E Alvarez

7

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13 September 2017

K Vanderkerken

8

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13 September 2017

language of work or name

English

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publication date

3 June 2008

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British Journal of Cancer

13 September 2017

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13 September 2017

98

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13 September 2017

12

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13 September 2017

1966-1974

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604388

13 September 2017

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The role of the bone marrow microenvironment in multiple myeloma

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Stem-cell transplantation in multiple myeloma

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Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.

14 September 2017

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14 September 2017

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14 September 2017

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Murine 5T multiple myeloma cells induce angiogenesis in vitro and in vivo

14 September 2017

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Chromosome translocations in multiple myeloma

14 September 2017

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Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse

14 September 2017

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The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins

14 September 2017

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A model of multiple myeloma: culture of 5T33 murine myeloma cells and evaluation of tumorigenicity in the C57BL/KaLwRij mouse

14 September 2017

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JNK activation is critical for Aplidin-induced apoptosis.

14 September 2017

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Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.

14 September 2017

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Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

14 September 2017

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Selective transendothelial migration of hematopoietic progenitor cells: a role in homing of progenitor cells.

14 September 2017

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Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines

25 September 2017

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Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma

25 September 2017

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Animal model of human disease. Multiple myeloma.

15 June 2018

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Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial

15 June 2018

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Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

21 August 2018

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VEGF inhibition and cytotoxic effect of aplidin in leukemia cell lines and cells from acute myeloid leukemia.

21 August 2018

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Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

21 August 2018

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Microvessel density, endothelial-cell proliferation and carbonic anhydrase IX expression in haematological malignancies, bone-marrow metastases and monoclonal gammopathy of undetermined significance.

21 August 2018

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Single versus double autologous stem-cell transplantation for multiple myeloma.

21 August 2018

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In vitro toxicity of three new antitumoral drugs (trabectedin, aplidin, and kahalalide F) on hematopoietic progenitors and stem cells

21 August 2018

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In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: a rational basis for clinical development

21 August 2018

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Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441967

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441967

Role of the bone marrow microenvironment in multiple myeloma

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441967

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441967

Part of the multiple myeloma-associated microvessels is functionally connected to the systemic circulation: a study in the murine 5T33MM model

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604388

Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604388

Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation

21 January 2018

1 reference

12 December 2020

Inhibition of p38alpha mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma

1 reference

12 December 2020

Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta

1 reference

12 December 2020

Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma

1 reference

12 December 2020

The 5T2MM murine model of multiple myeloma: maintenance and analysis

1 reference

12 December 2020

1 reference

12 December 2020

Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates

1 reference

12 December 2020

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

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12 December 2020

Measurement of apoptosis and proliferation of bone marrow plasma cells in patients with plasma cell proliferative disorders

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6604388

1 reference

13 September 2017

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13 September 2017

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