Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis (Q39627618)

13 September 2017

title

Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis (English)

1 reference

13 September 2017

1 reference

Nyree Crawford

1

1 reference

13 September 2017

Alex D Chacko

2

1 reference

13 September 2017

Kienan I Savage

3

1 reference

13 September 2017

Francis McCoy

4

1 reference

13 September 2017

Kelly Redmond

5

1 reference

13 September 2017

Daniel B Longley

6

1 reference

13 September 2017

Dean A Fennell

7

1 reference

13 September 2017

publication date

1 March 2011

1 reference

13 September 2017

1 reference

13 September 2017

volume

16

1 reference

13 September 2017

issue

3

1 reference

13 September 2017

page(s)

311-320

1 reference

https://scigraph.springernature.com/pub.10.1007/s10495-010-0561-1

13 September 2017

exact match

0 references

cites work

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

BID regulation by p53 contributes to chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Proapoptotic BID is an ATM effector in the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

A role for mitochondrial Bak in apoptotic response to anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Different forms of cell death induced by putative BCL2 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

10.1007/S10495-010-0561-1

21 January 2018

Identifiers

DOI

1 reference

13 September 2017

1 reference