Transporter-mediated drug--drug interactions involving OATP substrates: predictions based on in vitro inhibition studies. (Q39624755)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22534868%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Transporter-mediated drug--drug interactions involving OATP substrates: predictions based on in vitro inhibition studies (English)

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30 January 2020

1

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30 January 2020

author name string

K Maeda

series ordinal

2

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30 January 2020

Y Sugiyama

series ordinal

3

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30 January 2020

language of work or name

English

0 references

publication date

1 June 2012

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Clinical Pharmacology & Therapeutics

30 January 2020

published in

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30 January 2020

volume

91

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30 January 2020

issue

6

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30 January 2020

page(s)

1053-1064

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Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

30 January 2020

cites work

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Impact of OATP transporters on pharmacokinetics

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Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

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Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions

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Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

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Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.

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Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

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Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

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Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

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Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

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Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study.

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Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

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Effect of a selective CYP2C9 inhibitor on the pharmacokinetics of nateglinide in healthy subjects

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Studies on the interactions between drugs and estrogen. III. Inhibitory effects of 29 drugs reported to induce gynecomastia on the glucuronidation of estradiol

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Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans

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Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

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Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats

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Cyclosporine A, but not tacrolimus, shows relevant inhibition of organic anion-transporting protein 1B1-mediated transport of atorvastatin

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Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.

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Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

21 January 2018

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Characterization of uremic toxin transport by organic anion transporters in the kidney

21 January 2018

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Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.

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Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor

21 January 2018

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A pharmacokinetic analysis program (multi) for microcomputer

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Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

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Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

21 January 2018

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Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein

21 January 2018

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Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.351

inferred from DOI database lookup

7 January 2021

based on heuristic

Physiological parameters in laboratory animals and humans

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.351