Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells (Q39616429)

13 September 2017

Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells (English)

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13 September 2017

Chung Kwon Kim

1

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13 September 2017

Truong L X Nguyen

2

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13 September 2017

Sang Bae Lee

3

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13 September 2017

Sang Bum Park

4

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13 September 2017

Kyung-Hoon Lee

5

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13 September 2017

Sung-Woo Cho

6

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13 September 2017

Jee-Yin Ahn

7

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13 September 2017

language of work or name

English

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publication date

21 December 2010

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Experimental Cell Research

13 September 2017

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13 September 2017

317

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13 September 2017

7

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13 September 2017

966-975

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A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

13 September 2017

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Akt kinases in breast cancer and the results of adjuvant therapy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Deregulated Akt3 activity promotes development of malignant melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Role of nucleophosmin in embryonic development and tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Nucleophosmin regulates the stability and transcriptional activity of p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Nucleophosmin sets a threshold for p53 response to UV radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Characterization of gene expression in clinical lung cancer materials by two-dimensional polyacrylamide gel electrophoresis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Detection of polypeptides associated with the histopathological differentiation of primary lung carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.013

10.1016/J.YEXCR.2010.12.013

7 January 2021

Identifiers

DOI

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13 September 2017

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