A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia (Q39510346)

7 June 2018

title

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia (English)

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7 June 2018

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23

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author name string

Ivana Gojo

1

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7 June 2018

Jan H Beumer

2

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7 June 2018

Keith W Pratz

3

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7 June 2018

Michael A McDevitt

4

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7 June 2018

Maria R Baer

5

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7 June 2018

Amanda L Blackford

6

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7 June 2018

B Douglas Smith

7

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7 June 2018

Steven D Gore

8

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7 June 2018

Hetty E Carraway

9

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7 June 2018

Margaret M Showel

10

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7 June 2018

Mark J Levis

11

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7 June 2018

Amy E Dezern

12

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7 June 2018

Douglas E Gladstone

13

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7 June 2018

Jiuping Jay Ji

14

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7 June 2018

Lihua Wang

15

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7 June 2018

Robert J Kinders

16

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Marie Pouquet

17

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Ismail Ali-Walbi

18

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7 June 2018

Michelle A Rudek

19

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7 June 2018

Weijie Poh

20

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James G Herman

21

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Larry M Karnitz

22

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7 June 2018

Alice Chen

24

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Judith E Karp

25

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language of work or name

English

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publication date

8 August 2016

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7 June 2018

published in

Clinical Cancer Research

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7 June 2018

volume

23

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7 June 2018

issue

3

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7 June 2018

page(s)

697-706

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7 June 2018

Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors

cites work

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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

15 June 2018

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Toward Individualized Therapy in Acute Myeloid Leukemia: A Contemporary Review

15 June 2018

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A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - An

15 June 2018

1 reference

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Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.

15 June 2018

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New strategies in acute myelogenous leukemia: leukemogenesis and personalized medicine

15 June 2018

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Complex disease-, gene-, and drug-drug interactions: impacts of renal function, CYP2D6 phenotype, and OCT2 activity on veliparib pharmacokinetics

15 June 2018

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Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition

15 June 2018

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The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells.

15 June 2018

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Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis

15 June 2018

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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

15 June 2018

1 reference

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A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells

15 June 2018

1 reference

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RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

15 June 2018

1 reference

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Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia

15 June 2018

1 reference

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity

15 June 2018

1 reference

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma

15 June 2018

1 reference

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Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

DNA damage accumulation and repair defects in acute myeloid leukemia: implications for pathogenesis, disease progression, and chemotherapy resistance

15 June 2018

1 reference

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Clinical relevance of MGMT in the treatment of cancer

17 June 2018

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Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high-risk myelodysplastic syndrome patients pre-screened for low O(6) -methylguanine DNA methyltransferase expression

17 June 2018

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A phase II study of timed sequential therapy of acute myelogenous leukemia (AML) for patients over the age of 60: two cycle timed sequential therapy with topotecan, ara-C and mitoxantrone in adults with poor-risk AML.

21 August 2018

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Phase I study of temozolomide in relapsed/refractory acute leukemia

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Involvement of the mismatch repair system in temozolomide-induced apoptosis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Reutilization of Immunoblots after Chemiluminescent Detection

2 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Altered formation of topotecan-stabilized topoisomerase I-DNA adducts in human leukemia cells

2 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5290001

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

2 December 2018

1 reference

12 December 2020

Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study

1 reference

12 December 2020

A phase II study of temozolomide therapy for poor-risk patients aged >or=60 years with acute myeloid leukemia: low levels of MGMT predict for response

1 reference

12 December 2020

Population pharmacokinetic modeling of veliparib (ABT-888) in patients with non-hematologic malignancies

1 reference

12 December 2020

10.1158/1078-0432.CCR-16-0984

Identifiers

DOI

1 reference

7 June 2018

release_jaje5b5tuvbnbgdkh52kocf2oq

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jaje5b5tuvbnbgdkh52kocf2oq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

5290001

1 reference

7 June 2018

PubMed publication ID

27503200

1 reference

7 June 2018