Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant (Q39500562)

12 September 2017

Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant (English)

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12 September 2017

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Ben A Oostra

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12 September 2017

Andreea S Pop

1

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12 September 2017

Josien Levenga

2

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12 September 2017

Celine E F de Esch

3

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12 September 2017

Ronald A M Buijsen

4

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12 September 2017

Ingeborg M Nieuwenhuizen

5

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12 September 2017

Tracy Li

6

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12 September 2017

Aaron Isaacs

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12 September 2017

Fabrizio Gasparini

8

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12 September 2017

Rob Willemsen

10

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21 December 2012

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231

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1227-1235

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6

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https://scigraph.springernature.com/pub.10.1007/s00213-012-2947-y

12 September 2017

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Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

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Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome

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The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo.

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Which comes first in fragile X syndrome, dendritic spine dysgenesis or defects in circuit plasticity?

21 January 2018

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Dendritic Spine "Dysgenesis" and Mental Retardation

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Adult fragile X syndrome. Clinico-neuropathologic findings.

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Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome.

21 January 2018

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Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

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Abnormal development of dendritic spines in FMR1 knock-out mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23254376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00213-012-2947-Y

1 reference

release_rrbwogokpvgx5mjbgufr3zdyt4

12 September 2017

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