Copper inducing Aβ42 rather than Aβ40 nanoscale oligomer formation is the key process for Aβ neurotoxicity (Q39467227)

12 September 2017

Copper inducing Aβ42 rather than Aβ40 nanoscale oligomer formation is the key process for Aβ neurotoxicity (English)

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12 September 2017

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Lu Jin

1

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12 September 2017

Wei-Hui Wu

2

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12 September 2017

Qiu-Ye Li

3

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12 September 2017

Yu-Fen Zhao

4

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12 September 2017

Yan-Mei Li

5

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12 September 2017

language of work or name

English

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publication date

26 September 2011

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12 September 2017

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12 September 2017

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11

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12 September 2017

4746-4751

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

12 September 2017

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https://api.crossref.org/works/10.1039%2FC1NR11029B

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Amyloid beta-protein assembly and Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Metals and amyloid-beta in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Cu(2+) Inhibits the Aggregation of Amyloid beta-Peptide(1-42) in vitro We thank JEOL for the AFM measurement. This work was supported in part by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports, and Culture, and a Grant from "R

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

The metallobiology of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Copper enhances amyloid-beta peptide neurotoxicity and non beta-aggregation: a series of experiments conducted upon copper-bound and copper-free amyloid-beta peptide

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NR11029B

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Cu(II) binding to monomeric, oligomeric, and fibrillar forms of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NR11029B

Protein conformational misfolding and amyloid formation: characteristics of a new class of disorders that include Alzheimer's and Prion diseases

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Protein misfolding, functional amyloid, and human disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Amyloid ion channels: a common structural link for protein-misfolding disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Effects of lactose permease of Escherichia coli on the anisotropy and electrostatic surface potential of liposomes

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (A beta 1-40), which may potentially inhibit the fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NR11029B

Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2+ ions at physiological concentrations

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

Deconvoluting the Cu2+ binding modes of full-length prion protein

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1NR11029B

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NR11029B

21 January 2018

Identifiers

DOI

10.1039/C1NR11029B

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12 September 2017

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