Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents (Q39947061)

15 September 2017

Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents (English)

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15 September 2017

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11

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15 September 2017

Adam P Gunn

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author name string

Wei-hui Wu

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15 September 2017

Qian Liu

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15 September 2017

Jia Hu

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15 September 2017

Mei-sha Chen

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15 September 2017

Yan-fang Rui

7

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15 September 2017

Xiao-yang Su

8

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15 September 2017

Zuo-ping Xie

9

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15 September 2017

Yu-Fen Zhao

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15 September 2017

Yan-mei Li

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15 September 2017

language of work or name

English

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publication date

26 August 2008

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Journal of Biological Chemistry

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15 September 2017

283

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46

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15 September 2017

31657-31664

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

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Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease

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100 years and counting: prospects for defeating Alzheimer's disease

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

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Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

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Copper, iron and zinc in Alzheimer's disease senile plaques.

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

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Strategies for disease modification in Alzheimer's disease

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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Cleavage agents for soluble oligomers of amyloid beta peptides.

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Synthetic artificial peptidases and nucleases using macromolecular catalytic systems

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Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

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L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

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Binding of Zn(II), Cu(II), and Fe(II) ions to Alzheimer's A beta peptide studied by fluorescence

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

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A specific amyloid-beta protein assembly in the brain impairs memory

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NMDA receptor activation mediates copper homeostasis in hippocampal neurons

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

21 January 2018

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Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

21 January 2018

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Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins

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Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

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Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

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A native to amyloidogenic transition regulated by a backbone trigger

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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21 January 2018

Identifiers

DOI

10.1074/JBC.M804722200

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15 September 2017

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