PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA (Q39430828)

11 September 2017

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA (English)

1 reference

Poly(ADP-ribose) polymerase family member 3

11 September 2017

1 reference

protein ADP-ribosylase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Herwig Schüler

series ordinal

4

1 reference

11 September 2017

5

1 reference

11 September 2017

2

Ann-Sofie Jemth

1 reference

11 September 2017

7

Thomas Helleday

1 reference

11 September 2017

Olga Loseva

1

1 reference

11 September 2017

Helen E Bryant

series ordinal

3

1 reference

11 September 2017

Tobias Karlberg

series ordinal

6

1 reference

11 September 2017

language of work or name

English

0 references

publication date

11 January 2010

1 reference

Journal of Biological Chemistry

11 September 2017

1 reference

11 September 2017

285

1 reference

11 September 2017

8054-8060

1 reference

11 September 2017

11

1 reference

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Assessment of PARP-3 distribution in tissues of cynomolgous monkeys

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

DNA repair pathways as targets for cancer therapy

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Large-scale mapping of human protein-protein interactions by mass spectrometry

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Poly(ADP-ribose): novel functions for an old molecule

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Role of poly(ADP-ribose) formation in DNA repair

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

High resolution size analysis of ADP-ribose polymers using modified DNA sequencing gels

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation).

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

The 40 kDa carboxy-terminal domain of poly(ADP-ribose) polymerase-1 forms catalytically competent homo- and heterodimers in the absence of DNA.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832956

ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20064938

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20064938

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.077834

1 reference

release_e3yotw4rmbdwrl36ebtwhp6q3i

11 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/e3yotw4rmbdwrl36ebtwhp6q3i

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

11 September 2017

1 reference