The role and therapeutic potential of melatonin in age-related ocular diseases. (Q39402838)

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24 March 2020

review article

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title

The role and therapeutic potential of melatonin in age-related ocular diseases (English)

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24 March 2020

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24 March 2020

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Almudena Crooke

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1

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24 March 2020

Fernando Huete-Toral

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2

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24 March 2020

Basilio Colligris

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3

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18 July 2017

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Journal of Pineal Research

24 March 2020

published in

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63

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issue

2

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An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging

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Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma

21 January 2018

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Modulation of mitochondria in the axon and soma of retinal ganglion cells in a rat glaucoma model

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Changes in aqueous humor dynamics with age and glaucoma

21 January 2018

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21 January 2018

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Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma

21 January 2018

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21 January 2018

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Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma

21 January 2018

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21 January 2018

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21 January 2018

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Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma.

21 January 2018

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21 January 2018

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21 January 2018

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Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma

21 January 2018

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The role of blood pressure in glaucoma

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Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia

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Oral treatment with the melatonin agonist agomelatine lowers the intraocular pressure of glaucoma patients.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbits

21 January 2018

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Melatonin receptors trigger cAMP production and inhibit chloride movements in nonpigmented ciliary epithelial cells

21 January 2018

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Involvement of carbonic anhydrases in the ocular hypotensive effect of melatonin analogue 5-MCA-NAT.

21 January 2018

1 reference

Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma.

21 January 2018

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Melatonin: a novel neuroprotectant for the treatment of glaucoma

21 January 2018

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Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death.

21 January 2018

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Nitric oxide (NO): an emerging target for the treatment of glaucoma

21 January 2018

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Nitric oxide/guanylate cyclase pathways and flow in anterior segment perfusion

21 January 2018

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Elevation of nitric oxide production in human trabecular meshwork by increased pressure

21 January 2018

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Endogenous regulation of human Schlemm's canal cell volume by nitric oxide signaling

21 January 2018

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SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease

21 January 2018

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SIRT1 promotes RGC survival and delays loss of function following optic nerve crush

21 January 2018

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Neuroprotective effect of melatonin in experimental optic neuritis in rats

21 January 2018

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The effect of melatonin on retinal ganglion cell survival in ischemic retina

21 January 2018

1 reference

Melatonin-mediated cytoprotection against hyperglycemic injury in Müller cells

21 January 2018

1 reference

Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve

21 January 2018

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Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model

21 January 2018

1 reference

Mechanisms of acute axonal degeneration in the optic nerve in vivo

21 January 2018

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Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

21 January 2018

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Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure

21 January 2018

1 reference

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice.

21 January 2018

1 reference

Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells

21 January 2018

1 reference

Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model

21 January 2018

1 reference

An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma

21 January 2018

1 reference

Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress.

21 January 2018

1 reference

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis

21 January 2018

1 reference

Autophagic dysregulation in glaucomatous trabecular meshwork cells

21 January 2018

1 reference

Melatonin induces autophagy via an mTOR-dependent pathway and enhances clearance of mutant-TGFBIp.

21 January 2018

1 reference

Visual impairment and blindness due to macular diseases globally: a systematic review and meta-analysis

21 January 2018

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Mechanism of inflammation in age-related macular degeneration

21 January 2018

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Age-Related Macular Degeneration

21 January 2018

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The retinal pigment epithelium in visual function

21 January 2018

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Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.

21 January 2018

1 reference

Oxidative stress, polyunsaturated fatty acids-derived oxidation products and bisretinoids as potential inducers of CNS diseases: focus on age-related macular degeneration

21 January 2018

1 reference

Blue light induces mitochondrial DNA damage and free radical production in epithelial cells

21 January 2018

1 reference

Mitochondrial DNA damage and its potential role in retinal degeneration

21 January 2018

1 reference

Rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium

21 January 2018

1 reference

Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis

21 January 2018

1 reference

Mitochondrial decay and impairment of antioxidant defenses in aging RPE cells

21 January 2018

1 reference

Nrf2 signaling is impaired in the aging RPE given an oxidative insult

21 January 2018

1 reference

Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration

21 January 2018

1 reference

Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration

21 January 2018

1 reference

Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration

21 January 2018

1 reference

Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration

21 January 2018

1 reference

Investigating mitochondria as a target for treating age-related macular degeneration

21 January 2018

1 reference

Anti-apoptotic effects of melatonin in retinal pigment epithelial cells.

21 January 2018

1 reference

Melatonin delays photoreceptor degeneration in the rds/rds mouse

21 January 2018

1 reference

Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress

21 January 2018

1 reference

All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress

21 January 2018

1 reference

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

21 January 2018

1 reference

Effects of melatonin in age-related macular degeneration

21 January 2018

1 reference

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

21 January 2018

1 reference

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat

21 January 2018

1 reference

Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa

21 January 2018

1 reference

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

21 January 2018

1 reference

RPE lipofuscin and its role in retinal pathobiology

21 January 2018

1 reference

Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells

21 January 2018

1 reference

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

21 January 2018

1 reference

Oxidative damage-induced inflammation initiates age-related macular degeneration.

21 January 2018

1 reference

Systemic complement activation in age-related macular degeneration

21 January 2018

1 reference

NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration

21 January 2018

1 reference

Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration

21 January 2018

1 reference

NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration

21 January 2018

1 reference

Photoreceptor Outer Segments: Accelerated Membrane Renewal in Rods After Exposure to Light

21 January 2018

1 reference

Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium.

21 January 2018

1 reference

Methoxyindoles and photoreceptor metabolism: activation of rod shedding

21 January 2018

1 reference

Circadian control of photoreceptor outer segment membrane turnover in mice genetically incapable of melatonin synthesis

21 January 2018

1 reference

Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea-pigs,Cavia porcellus

21 January 2018

1 reference

Melanin photoprotection in the human retinal pigment epithelium and its correlation with light-induced cell apoptosis

21 January 2018

1 reference

Properties and function of the ocular melanin--a photobiophysical view

21 January 2018

1 reference

Loss of melanin from human RPE with aging: possible role of melanin photooxidation

21 January 2018

1 reference

Expression of telomerase reverse transcriptase in adult goldfish retina.

21 January 2018

1 reference

Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration

21 January 2018

1 reference

Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity

21 January 2018

1 reference

Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy

21 January 2018

1 reference

Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells.

21 January 2018

1 reference

Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration

21 January 2018

1 reference

Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments

21 January 2018

1 reference

Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization

21 January 2018

1 reference

Blood-retinal barrier disruption and ultrastructural changes in the hypoxic retina in adult rats: the beneficial effect of melatonin administration.

21 January 2018

1 reference

Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for neovascular age-related macular degeneration

21 January 2018

1 reference

Defining response to anti-VEGF therapies in neovascular AMD

21 January 2018

1 reference

Diabetic retinopathy and angiogenesis

21 January 2018

1 reference

Epidemiology of diabetes and diabetes complications in the elderly: an emerging public health burden

21 January 2018

1 reference

Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy

21 January 2018

1 reference

21 January 2018

Arginase in retinopathy

1 reference

Oxidative stress, mitochondrial damage and diabetic retinopathy

21 January 2018

1 reference

Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy

21 January 2018

1 reference

Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes

21 January 2018

1 reference

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

21 January 2018

1 reference

Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system.

21 January 2018

1 reference

Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy

21 January 2018

1 reference

Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase

21 January 2018

1 reference

Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia

21 January 2018

1 reference

A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy

21 January 2018

1 reference

Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy

21 January 2018

1 reference

Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats

21 January 2018

1 reference

Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin

21 January 2018

1 reference

Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats

21 January 2018

1 reference

Therapeutic efficacy of melatonin in reducing retinal damage in an experimental model of early type 2 diabetes in rats.

21 January 2018

1 reference

Early-stage retinal melatonin synthesis impairment in streptozotocin-induced diabetic wistar rats.

21 January 2018

1 reference

SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

21 January 2018

1 reference

Alteration of melatonin secretion in patients with type 2 diabetes and proliferative diabetic retinopathy

21 January 2018

1 reference

Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9.

21 January 2018

1 reference

Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina

21 January 2018

1 reference

NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina

21 January 2018

1 reference

Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells.

21 January 2018

1 reference

Retinal localization of the glutamate receptor GluR2 and GluR2-regulating proteins in diabetic rats

21 January 2018

1 reference

Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.

21 January 2018

1 reference

Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress

21 January 2018

1 reference

Advances in geroscience: impact on healthspan and chronic disease

21 January 2018

1 reference

Genetic evidence for common pathways in human age-related diseases

21 January 2018

1 reference

Müller cell-derived VEGF is a significant contributor to retinal neovascularization

21 January 2018

1 reference

Treatment of dry age-related macular degeneration.

21 January 2018

1 reference

Neovascular glaucoma: a review

21 January 2018

1 reference

Oxidative stress and the regulation of complement activation in human glaucoma

21 January 2018

1 reference

Combination therapy for the treatment of neovascular age-related macular degeneration.

21 January 2018

1 reference

Pharmacological management of primary open-angle glaucoma: second-line options and beyond

21 January 2018

1 reference

Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014).

21 January 2018

1 reference

Melatonin: action as antioxidant and potential applications in human disease and aging

21 January 2018

1 reference

Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

21 January 2018

1 reference

Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults

21 January 2018

1 reference

Melatonin pharmacokinetics in premenopausal and postmenopausal healthy female volunteers

21 January 2018

1 reference

Pharmacokinetics of orally administered melatonin in critically ill patients

21 January 2018

1 reference

Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.

21 January 2018

1 reference

Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat.

21 January 2018

1 reference

Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis

21 January 2018

1 reference

The role of antioxidants in the chemistry of oxidative stress: A review

21 January 2018

1 reference

Insulin signaling meets mitochondria in metabolism

21 January 2018

1 reference

21 January 2018

Cyclooxygenases 1 and 2

1 reference

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

21 January 2018

1 reference

Learning-induced enhancement of feedback inhibitory synaptic transmission

21 January 2018

1 reference

Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JPI.12430

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28658514%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

1 reference