Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non-homologous end joining DNA repair (Q39398108)

11 September 2017

title

Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non-homologous end joining DNA repair (English)

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11 September 2017

Meghan J McFadden

1

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11 September 2017

Wilson K Y Lee

series ordinal

2

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11 September 2017

John D Brennan

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3

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11 September 2017

Murray S Junop

series ordinal

4

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11 September 2017

language of work or name

English

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publication date

20 September 2013

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11 September 2017

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11 September 2017

volume

82

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11 September 2017

issue

2

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11 September 2017

page(s)

187-194

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Targeting DNA repair mechanisms in cancer

11 September 2017

cites work

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DNA repair dysregulation from cancer driver to therapeutic target

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DNA repair and resistance of gliomas to chemotherapy and radiotherapy

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Targeting DNA repair pathways: a novel approach to reduce cancer therapeutic resistance

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DNA repair pathways as targets for cancer therapy

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DNA repair inhibition: a selective tumour targeting strategy.

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The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

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Targeting the DNA damage response in oncology: past, present and future perspectives

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Synthetic lethality: exploiting the addiction of cancer to DNA repair

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner

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Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo

21 January 2018

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Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies

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The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer

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The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons.

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Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation

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Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate

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Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K

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Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

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Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

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DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs

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SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization

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A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

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Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

21 January 2018

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Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

21 January 2018

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An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression

21 January 2018

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Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair

21 January 2018

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Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein

21 January 2018

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Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4

21 January 2018

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Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

21 January 2018

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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

21 January 2018

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

21 January 2018

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Crystal structure of an Xrcc4-DNA ligase IV complex

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24349

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

21 January 2018

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DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24349

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

21 January 2018

Identifiers

DOI

10.1002/PROT.24349

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11 September 2017

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