Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair (Q24645423)

1

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Shijun Zhong

2

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Xiao Zhu

3

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Barbara Dziegielewska

4

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Gerald M Wilson

6

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Alexander D MacKerell

7

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Alan E Tomkinson

Human cancers express a mutator phenotype

8

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language of work or name

English

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publication date

1 May 2008

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published in

Cancer Research

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volume

68

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page(s)

3169-77

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issue

9

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cites work

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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

7 April 2017

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DNA end-joining catalyzed by human cell-free extracts

7 April 2017

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DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

7 April 2017

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An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining

7 April 2017

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Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

7 April 2017

1 reference

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An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III

7 April 2017

1 reference

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

7 April 2017

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DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

7 April 2017

1 reference

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Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

7 April 2017

1 reference

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

7 April 2017

1 reference

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Human DNA ligase I completely encircles and partially unwinds nicked DNA

7 April 2017

1 reference

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Early embryonic lethality due to targeted inactivation of DNA ligase III

7 April 2017

1 reference

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Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair

7 April 2017

1 reference

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BRCA2 is required for homology-directed repair of chromosomal breaks

7 April 2017

1 reference

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Brca1 controls homology-directed DNA repair

7 April 2017

1 reference

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Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

7 April 2017

1 reference

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Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice

27 September 2017

1 reference

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Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes

27 September 2017

1 reference

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DNA ligases: structure, reaction mechanism, and function

27 September 2017

1 reference

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Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.

27 September 2017

1 reference

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DNA repair inhibition: a selective tumour targeting strategy.

27 September 2017

1 reference

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Identification of novel extracellular signal-regulated kinase docking domain inhibitors.

27 September 2017

1 reference

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DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Development of non-electrophoretic assay method for DNA ligases and its application to screening of chemical inhibitors of DNA ligase I.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Elevated expression of DNA ligase I in human cancers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

A geometric approach to macromolecule-ligand interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Simian virus 40 DNA replication in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Location of the active site for enzyme-adenylate formation in DNA ligases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Natural-product inhibitors of human DNA ligase I.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Studies on camptothecin. I. Effects of nucleic acid and protein synthesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734474

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18451142

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two Pathways for Base Excision Repair in Mammalian Cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18451142