Targeting sphingosine-1-phosphate signaling for cancer therapy (Q39379449)

11 September 2017

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title

Targeting sphingosine-1-phosphate signaling for cancer therapy (English)

1 reference

11 September 2017

Zuoquan Xie

1

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PubMed ID

28623546

11 September 2017

Hong Liu

series ordinal

2

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PubMed ID

28623546

11 September 2017

Meiyu Geng

series ordinal

3

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11 September 2017

27 May 2017

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Science in China. Series C: Life Sciences

11 September 2017

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11 September 2017

60

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11 September 2017

585-600

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11 September 2017

6

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https://scigraph.springernature.com/pub.10.1007/s11427-017-9046-6

11 September 2017

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cites work

Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

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Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.

21 January 2018

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Sphingosine-1-phosphate receptors and the development of the vascular system

21 January 2018

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

21 January 2018

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Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.

21 January 2018

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Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Combined anticancer effects of sphingosine kinase inhibitors and sorafenib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Second generation S1P pathway modulators: research strategies and clinical developments.

21 January 2018

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Differential effects of ponesimod, a selective S1P1 receptor modulator, on blood-circulating human T cell subpopulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine 1-phosphate analogs as receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Role of TH17 cytokines in the control of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Transduction of Multiple Effects of Sphingosine 1-Phosphate (S1P) on T Cell Functions by the S1P1 G Protein-Coupled Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Development of small-molecule inhibitors of sphingosine-1-phosphate signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Antitumor activity of sphingosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Identification of the hydrophobic ligand binding pocket of the S1P1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate receptor 1 (S1PR1) expression in non-muscle invasive urothelial carcinoma: Association with poor clinical outcome and potential therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Endothelial differentiation gene-1, a new downstream gene is involved in RTEF-1 induced angiogenesis in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Ceramide as an activator lipid of cathepsin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Fingolimod for the treatment of relapsing multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Role for sphingosine kinase 1 in colon carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Multiple roles for CD4+ T cells in anti-tumor immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate and estrogen signaling in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Th17-cytokine blockers as a new approach for treating inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate in chronic intestinal inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The structure and function of the S1P1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Biologically active sphingolipids in cancer pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine 1-phosphate and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine 1-phosphate signalling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The alliance of sphingosine-1-phosphate and its receptors in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Central memory and effector memory T cell subsets: function, generation, and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Finding a way out: lymphocyte egress from lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeting SphK1 as a new strategy against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The outs and the ins of sphingosine-1-phosphate in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeting sphingosine-1-phosphate in hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeting sphingosine-1-phosphate receptors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

Sphingosine kinase 1 and cancer: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

TGF-β/SMAD3 Pathway Stimulates Sphingosine-1 Phosphate Receptor 3 Expression: IMPLICATION OF SPHINGOSINE-1 PHOSPHATE RECEPTOR 3 IN LUNG ADENOCARCINOMA PROGRESSION.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-017-9046-6

10.1007/S11427-017-9046-6

21 January 2018

Identifiers

DOI

1 reference

11 September 2017

1 reference

PubMed ID

28623546