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FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia (Q35945171)

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English	FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia	scientific article

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Europe PubMed Central

PMC publication ID

11 August 2017

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia (English)

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Europe PubMed Central

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11 August 2017

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Philadelphia chromosome

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Philadelphia chromosome

2 August 2024

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Carlo Gambacorti-Passerini

10

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Carlo Gambacorti-Passerini

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Bradley W Blaser

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Bradley W Blaser

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Nicole M Verrills

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Nicole M Verrills

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Brian J Druker

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Jorge Eduardo Cortes

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Jorge Cortes

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Guido Marcucci

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Clara D. Bloomfield

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Clara D Bloomfield

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John C Byrd

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11 August 2017

Michael A Caligiuri

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Michael A Caligiuri

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11 August 2017

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Anna M Eiring

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11 August 2017

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Shujun Liu

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11 August 2017

Natarajan Muthusamy

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Natarajan Muthusamy

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11 August 2017

Ramasamy Santhanam

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Ramasamy Santhanam

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11 August 2017

Danilo Perrotti

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Danilo Perrotti

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11 August 2017

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Paolo Neviani

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11 August 2017

3

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Joshua J Oaks

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11 August 2017

Shih-Ching Chen

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Ching-Shih Chen

1 reference

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11 August 2017

8

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Rossana Trotta

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11 August 2017

Denis Claude Roy

16

object named as

Denis C Roy

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11 August 2017

author name string

Mario Notari

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11 August 2017

publication date

1 September 2007

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11 August 2017

language of work or name

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Journal of Clinical Investigation

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11 August 2017

117

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11 August 2017

9

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Europe PubMed Central

PMC publication ID

11 August 2017

2408-2421

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Europe PubMed Central

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11 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1950458/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

1 reference

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2 October 2017

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

1 reference

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2 October 2017

Developing therapeutics for the treatment of multiple sclerosis

1 reference

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2 October 2017

FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma

1 reference

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1 reference

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2 October 2017

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

1 reference

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2 October 2017

Transformation of human and murine fibroblasts without viral oncoproteins

1 reference

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2 October 2017

Chronic myeloid leukaemia: stem cell derived but progenitor cell driven

1 reference

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2 October 2017

FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

1 reference

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2 October 2017

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants

1 reference

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2 October 2017

Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

Fingolimod. Mitsubishi Pharma/Novartis.

1 reference

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2 October 2017

U.S. Food and Drug Administration Drug Approval Summary: conversion of imatinib mesylate (STI571; Gleevec) tablets from accelerated approval to full approval

1 reference

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2 October 2017

FTY720: mechanism of action and potential benefit in organ transplantation

1 reference

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2 October 2017

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

1 reference

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2 October 2017

Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert

1 reference

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FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation

1 reference

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Biologically active sphingolipids in cancer pathogenesis and treatment

1 reference

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Biology of chronic myelogenous leukemia--signaling pathways of initiation and transformation

1 reference

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2 October 2017

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

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FTY720: from bench to bedside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

The biology of CML blast crisis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

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Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias

1 reference

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2 October 2017

Discovery and evaluation of inhibitors of human sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

The biology and therapy of adult acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

Involvement of protein phosphatase 2A in interferon-alpha-2b-induced apoptosis in K562 human chronic myelogenous leukaemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment

1 reference

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2 October 2017

Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.

1 reference

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2 October 2017

PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias

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2 October 2017

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

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Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

1 reference

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2 October 2017

Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

1 reference

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Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

1 reference

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2 October 2017

Protein phosphatase 2A: the Trojan Horse of cellular signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells

1 reference

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2 October 2017

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

1 reference

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2 October 2017

Modulation of Akt kinase activity by binding to Hsp90

1 reference

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2 October 2017

Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

1 reference

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2 October 2017

Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period

1 reference

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2 October 2017

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

1 reference

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

1 reference

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2 October 2017

Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

2 October 2017

Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

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Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells

1 reference

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Ceramide activates heterotrimeric protein phosphatase 2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

11 July 2018

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1 reference

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1 reference

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Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

1 reference

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1 reference

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Control of protein phosphatase 2A by simian virus 40 small-t antigen

1 reference

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Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)

1 reference

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FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

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Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

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Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

24 September 2018

Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

24 September 2018

FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

24 September 2018

Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells

1 reference

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24 September 2018

Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

24 September 2018

Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects

1 reference

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24 September 2018

First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

24 September 2018

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

24 September 2018

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950458

24 September 2018

Survival advantage from imatinib compared with the combination interferon- plus cytarabine in chronic-phase chronic myelogenous leukemia: historical comparison between two phase 3 trials

1 reference

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14 November 2018

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17717597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17717597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17717597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FTY720: a new immunosuppressive agent with novel mechanism(s) of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/17717597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17717597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17717597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI31095

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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