State of Play in Alzheimer's Disease Genetics (Q39307376)

10 September 2017

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title

State of Play in Alzheimer's Disease Genetics (English)

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10 September 2017

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Jin-Tai Yu

4

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Lan Tan

series ordinal

3

object named as

Lan Tan

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10 September 2017

Jin-Bao Zhu

1

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PubMed ID

28505974

10 September 2017

Chen-Chen Tan

series ordinal

2

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10 September 2017

11 May 2017

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Journal of Alzheimer's Disease

10 September 2017

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10 September 2017

58

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10 September 2017

3

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10 September 2017

631-659

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Role of Genes and Environments for Explaining Alzheimer Disease

10 September 2017

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Molecular genetics of early-onset Alzheimer's disease revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

gamma-secretases: from cell biology to therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer's disease genetics: from the bench to the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Clinical and neuroimaging characterization of Chinese dementia patients with PSEN1 and PSEN2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer's disease risk genes and mechanisms of disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic association between APP, ADAM10 gene polymorphism, and sporadic Alzheimer's disease in the Chinese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The genetic landscape of Alzheimer disease: clinical implications and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide analysis of genetic loci associated with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Examination of the current top candidate genes for AD in a genome-wide association study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide scan of copy number variation in late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A comprehensive genetic association study of Alzheimer disease in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association study of Alzheimer's disease with psychotic symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association study of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Clathrin interacts specifically with amphiphysin and is displaced by dynamin

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic variation and neuroimaging measures in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Comparative proteomic analysis of brains of naturally aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The membrane-tubulating potential of amphiphysin 2/BIN1 is dependent on the microtubule-binding cytoplasmic linker protein 170 (CLIP-170)

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Amyloid precursor protein trafficking, processing, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

CR1 in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35).

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Heterogeneity of endocytic proteins: distribution of clathrin adaptor proteins in neurons and glia

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic variation in PICALM and Alzheimer's disease risk in Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Distribution and expression of picalm in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Evidence for CALM in directing VAMP2 trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

An Overview of Genome-Wide Association Studies in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

SORL1 Is Associated with the Risk of Late-Onset Alzheimer's Disease: a Replication Study and Meta-Analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Coding mutations in SORL1 and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The Role of SORL1 in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

CD33 in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic susceptibility for Alzheimer disease neuritic plaque pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Evidence for impaired amyloid β clearance in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic modification of the relationship between phosphorylated tau and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Effect of CR1 Genetic Variants on Cerebrospinal Fluid and Neuroimaging Biomarkers in Healthy, Mild Cognitive Impairment and Alzheimer's Disease Cohorts

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Frontobasal gray matter loss is associated with the TREM2 p.R47H variant

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Impact of Common Variations in PLD3 on Neuroimaging Phenotypes in Non-demented Elders

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Association of plasma and cortical amyloid beta is modulated by APOE ε4 status

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI).

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Transcriptome-guided amyloid imaging genetic analysis via a novel structured sparse learning algorithm

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Interactions between GSK3β and amyloid genes explain variance in amyloid burden

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Extension and refinement of the predictive value of different classes of markers in ADNI: four-year follow-up data

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer's disease: rare variants with large effect sizes

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Identification of rare variants in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

TREM2 Function in Alzheimer's Disease and Neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

PLD3 in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

SnapShot: genetics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Defining the Genetic Architecture of Alzheimer's Disease: Where Next

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Editorial: Towards New Approaches in Alzheimer's Research and Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Pathways to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Convergent genetic and expression data implicate immunity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Microtubule-Tau Interaction as a Therapeutic Target for Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer's Disease: Lessons Learned from Amyloidocentric Clinical Trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

The TOMM40 gene rs2075650 polymorphism contributes to Alzheimer's disease in Caucasian, and Asian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Toward precision medicine in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Incomplete penetrance of familial Alzheimer's disease in a pedigree with a novel presenilin-1 gene mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Missense variants in CR1 are associated with increased risk of Alzheimer' disease in Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

Genetic variation modifies risk for neurodegeneration based on biomarker status.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170062

21 January 2018

Identifiers

DOI

10.3233/JAD-170062

1 reference

10 September 2017

1 reference

PubMed ID

28505974