Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma (Q39304634)

10 September 2017

Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma (English)

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10 September 2017

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Patrick Hwu

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Chantale Bernatchez

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Michael A Davies

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Jennifer A Wargo

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Zachary A Cooper

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Elizabeth Grimm

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Seth Wardell

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Chengwen Liu

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Jahan S Khalili

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Minying Zhang

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Mayra Whittington

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Gregory Lizée

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Dennie T Frederick

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Suhendan Ekmekcioglu

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Shujuan Liu

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Tania G Rodríguez-Cruz

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Yufeng Li

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Min Zhang

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Laszlo G Radvanyi

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Richard E Davis

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language of work or name

English

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publication date

31 July 2012

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10 September 2017

Clinical Cancer Research

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5329-5340

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describes a project that uses

10 September 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/3463754

inferred from PubMed Central ID database lookup

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Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum

11 September 2017

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Hematologic toxicities in cancer patients treated with the multi-tyrosine kinase sorafenib: a meta-analysis of clinical trials

11 September 2017

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Small-molecule protein kinase inhibitors and their effects on the immune system: implications for cancer treatment

11 September 2017

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Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

11 September 2017

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Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients

11 September 2017

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Hallmarks of cancer: interactions with the tumor stroma.

11 September 2017

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Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

11 September 2017

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Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model

11 September 2017

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Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

11 September 2017

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Immunogenic and tolerogenic cell death

11 September 2017

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The immunogenicity of tumor cell death

11 September 2017

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The anticancer immune response: indispensable for therapeutic success?

11 September 2017

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

11 September 2017

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Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy?

11 September 2017

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Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model

11 September 2017

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Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression

11 September 2017

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Less yin, more yang: confronting the barriers to cancer immunotherapy

11 September 2017

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Improving antitumor immune responses by circumventing immunoregulatory cells and mechanisms

11 September 2017

1 reference

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Immunosuppression in melanoma immunotherapy: potential opportunities for intervention

11 September 2017

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Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

11 September 2017

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Stromal fibroblasts in cancer initiation and progression

11 September 2017

1 reference

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Estimating the occurrence of false positives and false negatives in microarray studies by approximating and partitioning the empirical distribution of p-values

11 September 2017

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MAP kinases in the immune response

11 September 2017

1 reference

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Autocrine and paracrine regulation by cytokines and growth factors in melanoma

11 September 2017

1 reference

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Autocrine interleukin-1beta production in leukemia: evidence for the involvement of mutated RAS.

11 September 2017

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Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

11 September 2017

1 reference

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Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function

14 September 2017

1 reference

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Interleukins 1alpha and 1beta secreted by some melanoma cell lines strongly reduce expression of MITF-M and melanocyte differentiation antigens

14 September 2017

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Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors

14 September 2017

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Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma

14 September 2017

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PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

14 September 2017

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

14 September 2017

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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

14 September 2017

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The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells

14 September 2017

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Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression

14 September 2017

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V599EB-RAF is an oncogene in melanocytes

14 September 2017

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Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta

14 September 2017

1 reference

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Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463754

Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapy

21 August 2018

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Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463754

MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463754

Profound inhibition of antigen-specific T-cell effector functions by dasatinib

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3463754

E prostanoid 2 (EP2)/EP4-mediated suppression of antigen-specific human T-cell responses by prostaglandin E2.

21 August 2018

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Correlation between age and the secretions of melanocyte-stimulating cytokines in cultured keratinocytes and fibroblasts.

21 August 2018

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Immature immunosuppressive CD14+HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-sign

21 August 2018

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12 December 2020

Interleukin-1 production in tumor cells of human melanoma surgical specimens

1 reference

12 December 2020

Pneumocystis carinii pneumonia in patients receiving chemotherapy for breast cancer

1 reference

12 December 2020

Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells

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12 December 2020

10.1158/1078-0432.CCR-12-1632

Identifiers

DOI

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10 September 2017

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10 September 2017

1 reference