Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier (Q39297983)

10 September 2017

Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier (English)

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10 September 2017

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Corbin Bachmeier

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10 September 2017

David Beaulieu-Abdelahad

2

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10 September 2017

Fiona Crawford

3

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10 September 2017

Michael Mullan

4

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10 September 2017

Daniel Paris

5

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10 September 2017

14 August 2012

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Journal of Molecular Neuroscience

10 September 2017

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10 September 2017

49

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10 September 2017

2

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10 September 2017

270-276

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https://scigraph.springernature.com/pub.10.1007/s12031-012-9866-6

10 September 2017

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cites work

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Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

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Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

21 January 2018

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

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The retinoid X receptors and their ligands

21 January 2018

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apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

21 January 2018

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Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

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Adipocyte low density lipoprotein receptor-related protein gene expression and function is regulated by peroxisome proliferator-activated receptor gamma

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All-trans retinoic acid enhances the transport of phase II metabolites of benzo[a]pyrene by inducing the Breast Cancer Resistance Protein expression in Caco-2 cells

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ApoE promotes the proteolytic degradation of Abeta

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The role of apolipoprotein E in Alzheimer's disease

21 January 2018

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Secretion of apolipoprotein E from macrophages occurs via a protein kinase A and calcium-dependent pathway along the microtubule network

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Regulation of endogenous apolipoprotein E secretion by macrophages

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Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

21 January 2018

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MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.

21 January 2018

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Retinoid X receptors: common heterodimerization partners with distinct functions

21 January 2018

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A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

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Cell surface proteoglycans modulate net synthesis and secretion of macrophage apolipoprotein E.

21 January 2018

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Decreased clearance of CNS beta-amyloid in Alzheimer's disease

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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Amyloid beta protein as a marker or risk factor of Alzheimer's disease

21 January 2018

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Amyloid imaging in Alzheimer's disease.

21 January 2018

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Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier

21 January 2018

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Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

21 January 2018

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Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

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Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

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Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats

21 January 2018

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P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta

21 January 2018

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Peroxisome proliferator-activated receptor-gamma regulates the expression and function of very-low-density lipoprotein receptor

21 January 2018

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Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-012-9866-6

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-012-9866-6

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-012-9866-6

Peroxisome proliferator-activated receptor {gamma} stimulation of adipocyte ApoE gene transcription mediated by the liver receptor X pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-012-9866-6

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

21 January 2018

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Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches

21 January 2018

1 reference

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Amyloid β-protein precursor and apolipoprotein E production in cultured cerebral endothelial cells isolated from brains of patients with neurodegenerative disorders at autopsy

21 January 2018

1 reference

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Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrier

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22890420

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dynamic and stable pools of apoE differ functionally at the HepG2 cell surface.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22890420

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22890420

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S12031-012-9866-6

1 reference

10 September 2017

1 reference