Blood-Brain Barrier Protection as a Therapeutic Strategy for Acute Ischemic Stroke (Q39292959)

10 September 2017

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title

Blood-Brain Barrier Protection as a Therapeutic Strategy for Acute Ischemic Stroke (English)

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10 September 2017

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Ali Ehsan Sifat

1

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10 September 2017

Bhuvaneshwar Vaidya

series ordinal

2

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10 September 2017

Thomas J Abbruscato

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3

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10 September 2017

language of work or name

English

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publication date

8 May 2017

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10 September 2017

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10 September 2017

19

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10 September 2017

4

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10 September 2017

957-972

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https://scigraph.springernature.com/pub.10.1208/s12248-017-0091-7

10 September 2017

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Overexpression of Fibulin-5 Attenuates Ischemia/Reperfusion Injury After Middle Cerebral Artery Occlusion in Rats

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Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils

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Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke

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Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats

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Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study.

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Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke

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Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema

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Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke

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12 December 2020

Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability

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12 December 2020

Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury

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Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-β signaling.

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NXY-059 for acute ischemic stroke

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In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment

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Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

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12 December 2020

Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA

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Sodium transport through the cerebral sodium-glucose transporter exacerbates neuron damage during cerebral ischaemia.

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Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity.

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Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage

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12 December 2020

Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia

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A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion

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Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells

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12 December 2020

Nanoscale drug delivery systems and the blood-brain barrier

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12 December 2020

Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI.

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12 December 2020

Blood-brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions

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Stroke Neurologist's Perspective on the New Endovascular Trials

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12 December 2020

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12 December 2020

A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts

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12 December 2020

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12 December 2020

Oxidative stress and its role in the pathogenesis of ischaemic stroke

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12 December 2020

Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke

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12 December 2020

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12 December 2020

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12 December 2020

The blood-brain barrier after stroke: Structural studies and the role of transcytotic vesicles

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12 December 2020

Histochemical demonstration of free radicals (H2O2) in ischemic brain edema and protective effects of human recombinant superoxide dismutase on ischemic neuronal damage

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12 December 2020

Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway

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12 December 2020

Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins

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12 December 2020

Tobacco smoke chemicals attenuate brain-to-blood potassium transport mediated by the Na,K,2Cl-cotransporter during hypoxia-reoxygenation

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12 December 2020

MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia

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12 December 2020

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB).

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12 December 2020

Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats.

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12 December 2020

Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature rat brain

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12 December 2020

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

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12 December 2020

Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke

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12 December 2020

A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation

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12 December 2020

Neuroprotection from tissue inhibitor of metalloproteinase-1 and its nanoparticles

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12 December 2020

Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.

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12 December 2020

β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier

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12 December 2020

Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia

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12 December 2020

Peripheral markers of brain damage and blood-brain barrier dysfunction

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12 December 2020

Nanoparticle-based targeted drug delivery

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12 December 2020

Modulation by nitric oxide of cerebral neutrophil accumulation after transient focal ischemia in rats

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12 December 2020

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals.

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12 December 2020

In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

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12 December 2020

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo.

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12 December 2020

Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1.

1 reference

12 December 2020

Physiology and pathophysiology of matrix metalloproteases.

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12 December 2020

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator.

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12 December 2020

Structure and function of claudins.

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12 December 2020

Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke

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12 December 2020

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects.

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12 December 2020

Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia

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12 December 2020

Multiple roles for MMPs and TIMPs in cerebral ischemia

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12 December 2020

Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging.

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12 December 2020

Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association

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12 December 2020

Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia.

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12 December 2020

Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil

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12 December 2020

The tension mounts: stress fibers as force-generating mechanotransducers

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12 December 2020

Fine structural localization of a blood-brain barrier to exogenous peroxidase

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12 December 2020

Inflammation and the neurovascular unit in the setting of focal cerebral ischemia

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12 December 2020

The impact of microglial activation on blood-brain barrier in brain diseases.

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12 December 2020

Regulation of blood-brain barrier Na,K,2Cl-cotransporter through phosphorylation during in vitro stroke conditions and nicotine exposure

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12 December 2020

Tissue-type plasminogen activator: a multifaceted modulator of neurotransmission and synaptic plasticity.

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12 December 2020

Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process

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12 December 2020

Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions

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12 December 2020

Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases

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12 December 2020

Tissue-type plasminogen activator

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12 December 2020

Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

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12 December 2020

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.

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12 December 2020

Nanoparticulate systems for brain delivery of drugs

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12 December 2020

Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system

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12 December 2020

Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke

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12 December 2020

Pericytes regulate the blood-brain barrier

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12 December 2020

Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice

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12 December 2020

Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.

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12 December 2020

Targeting ischemic penumbra Part II: selective drug delivery using liposome technologies

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12 December 2020

Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke.

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12 December 2020

Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice

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12 December 2020

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation.

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12 December 2020

Molecular biomarkers in stroke diagnosis and prognosis

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12 December 2020

The effects of hypertension on the cerebral circulation

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12 December 2020

Normobaric hyperoxia slows blood-brain barrier damage and expands the therapeutic time window for tissue-type plasminogen activator treatment in cerebral ischemia

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12 December 2020

Cerebral glucose transporter: the possible therapeutic target for ischemic stroke

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12 December 2020

Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability

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12 December 2020

Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study

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12 December 2020

Identification of variations in blood-brain barrier opening after cerebral ischemia by dual contrast-enhanced magnetic resonance imaging and T 1sat measurements.

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12 December 2020

The role of glucose transporters in brain disease: diabetes and Alzheimer’s Disease

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12 December 2020

Combination of reactive oxygen species and tissue-type plasminogen activator enhances the induction of gelatinase B in brain endothelial cells

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12 December 2020

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

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12 December 2020

Evaluating therapeutic targets for reperfusion-related brain hemorrhage.

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12 December 2020

Blood-brain barrier tight junction permeability and ischemic stroke

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12 December 2020

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

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12 December 2020

Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94.

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12 December 2020

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat.

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12 December 2020

Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells

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12 December 2020

Cellular mechanisms of neurovascular damage and repair after stroke

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12 December 2020

Inflammatory mediators of cerebral endothelium: a role in ischemic brain inflammation.

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12 December 2020

Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke

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12 December 2020

Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice.

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12 December 2020

Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening.

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12 December 2020

Smoking and ischemic stroke: a role for nicotine?

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12 December 2020

Role of matrix metalloproteinases in delayed cortical responses after stroke.

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12 December 2020

Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator

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12 December 2020

Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells

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12 December 2020

The role of blood-brain barrier transporters in pathophysiology and pharmacotherapy of stroke

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12 December 2020

Receptor-mediated endocytosis and intracellular trafficking of lipoproteins and transferrin in insect cells.

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12 December 2020

Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling

1 reference

12 December 2020

Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.

1 reference

12 December 2020

Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance

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12 December 2020

Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro

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12 December 2020

Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling

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12 December 2020

Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats

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12 December 2020

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12 December 2020

Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.

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12 December 2020

Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator.

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12 December 2020

Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia.

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12 December 2020

10.1208/S12248-017-0091-7

Identifiers

DOI

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Dimensions Publication ID

10 September 2017

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