The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. (Q39285665)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18209086%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease (English)

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inflammatory bowel diseases

1 January 2020

main subject

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8

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1 January 2020

Maria T Abreu

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1 January 2020

author name string

Masayuki Fukata

1

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1 January 2020

Keith Breglio

2

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Anli Chen

3

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1 January 2020

Arunan S Vamadevan

4

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Tyralee Goo

5

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David Hsu

6

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Daisy Conduah

7

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language of work or name

English

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publication date

1 February 2008

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1 January 2020

published in

Journal of Immunology

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volume

180

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issue

3

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1 January 2020

page(s)

1886-1894

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Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

1 January 2020

cites work

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

10 September 2017

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Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

10 September 2017

1 reference

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Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

10 September 2017

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Toll-like receptor ligands directly promote activated CD4+ T cell survival

10 September 2017

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Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases.

10 September 2017

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A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis

14 September 2017

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Cytokines induce the development of functionally heterogeneous T helper cell subsets

14 September 2017

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CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease

15 June 2018

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Essential function for the kinase TAK1 in innate and adaptive immune responses.

15 June 2018

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Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.

21 August 2018

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Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation

21 August 2018

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Toll-dependent control mechanisms of CD4 T cell activation.

21 August 2018

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Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

21 August 2018

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In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting

21 August 2018

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Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.

21 August 2018

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 August 2018

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A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation

21 August 2018

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

2 December 2018

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Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

2 December 2018

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12 December 2020

Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients

1 reference

12 December 2020

CD4+ T-cells in the regulation of inflammatory responses in the intestine

1 reference

12 December 2020

In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)-deficient mice induce intestinal inflammation in immunodeficient hosts

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12 December 2020

Toll-like receptors control activation of adaptive immune responses

1 reference

12 December 2020

Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13–14 (IBD2)

1 reference

12 December 2020

Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17

1 reference

12 December 2020

Toll-like receptors: linking innate and adaptive immunity

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12 December 2020

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

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12 December 2020

TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis

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12 December 2020

Cutting edge: TLR2 directly triggers Th1 effector functions

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12 December 2020

Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease

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12 December 2020

Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling

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12 December 2020

Role of toll-like receptors in spontaneous commensal-dependent colitis

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12 December 2020

Innate immune activation and CD4+ T cell priming during respiratory fungal infection

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12 December 2020

10.4049/JIMMUNOL.180.3.1886

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18209086%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18209086%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

18209086

1 reference