The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres (Q39276216)

10 September 2017

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres (English)

1 reference

10 September 2017

Aaron Mendez-Bermudez

1

1 reference

10 September 2017

Alberto Hidalgo-Bravo

2

1 reference

10 September 2017

Victoria E Cotton

3

1 reference

10 September 2017

Athanasia Gravani

4

1 reference

10 September 2017

Jennie N Jeyapalan

5

1 reference

10 September 2017

Nicola J Royle

6

1 reference

10 September 2017

language of work or name

English

0 references

publication date

18 September 2012

1 reference

10 September 2017

Nucleic Acids Research

1 reference

10 September 2017

40

1 reference

10 September 2017

10809-10820

1 reference

10 September 2017

21

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Creative Commons Attribution 3.0 Unported

10 September 2017

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3510502/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells

10 September 2017

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Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes

10 September 2017

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Hyper telomere recombination accelerates replicative senescence and may promote premature aging

10 September 2017

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Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.

10 September 2017

1 reference

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Alternative lengthening of telomeres: models, mechanisms and implications

10 September 2017

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Mechanisms of recombination between diverged sequences in wild-type and BLM-deficient mouse and human cells

10 September 2017

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Unwinding protein complexes in ALTernative telomere maintenance

10 September 2017

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RecQ helicases: multifunctional genome caretakers

10 September 2017

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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

10 September 2017

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Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

10 September 2017

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Complex germline and somatic mutation processes at a haploid human minisatellite shown by single-molecule analysis

10 September 2017

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Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

10 September 2017

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How shelterin protects mammalian telomeres

10 September 2017

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Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases

10 September 2017

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Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres

10 September 2017

1 reference

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WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening

10 September 2017

1 reference

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How telomeres are replicated

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Replication and protection of telomeres

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomere dysfunction as a cause of genomic instability in Werner syndrome

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Break-induced replication and recombinational telomere elongation in yeast

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Evidence for multiple cycles of strand invasion during repair of double-strand gaps in Drosophila

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Two modes of germline instability at human minisatellite MS1 (locus D1S7): complex rearrangements and paradoxical hyperdeletion.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Loss of Werner syndrome protein function promotes aberrant mitotic recombination

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Binding and melting of D-loops by the Bloom syndrome helicase

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

An alternative pathway for yeast telomere maintenance rescues est1- senescence

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomere dynamics in an immortal human cell line

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomere elongation in immortal human cells without detectable telomerase activity

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Mutator phenotype of Werner syndrome is characterized by extensive deletions

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Allele-specific MVR-PCR analysis at minisatellite D1S8.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Four-state MVR-PCR: increased discrimination of digital DNA typing by simultaneous analysis of two polymorphic sites within minisatellite variant repeats at D1S8.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Hypervariable digital DNA codes for human paternal lineages: MVR-PCR at the Y-specific minisatellite, MSY1 (DYF155S1).

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The role of recombination in telomere length maintenance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

A novel telomere structure in a human alternative lengthening of telomeres cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomere maintenance by recombination in human cells.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The susceptibility of Werner's syndrome and other human skin fibroblasts to SV40-induced transformation and immortalization.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Extensive allelic variation and ultrashort telomeres in senescent human cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Extremely complex repeat shuffling during germline mutation at human minisatellite B6.7.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510502

Complex gene conversion events in germline mutation at human minisatellites

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKS862

The Bloom Syndrome Protein Limits the Lethality Associated with RAD51 Deficiency

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKS862

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22989712

12 December 2020

inferred from PubMed ID database lookup

SGS1 is required for telomere elongation in the absence of telomerase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22989712

12 December 2020

inferred from PubMed ID database lookup

Somatic mutation processes at a human minisatellite

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22989712

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/NAR/GKS862

1 reference

10 September 2017

1 reference

10 September 2017

1 reference