Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase. (Q39184995)

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25 February 2020

title

Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase (English)

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25 February 2020

8

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25 February 2020

author name string

Xingwu Wang

1

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25 February 2020

Meng Zha

2

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25 February 2020

Xiaocheng Zhao

3

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25 February 2020

Peng Jiang

4

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25 February 2020

Wenjing Du

5

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25 February 2020

Andrew Y H Tam

6

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25 February 2020

Yide Mei

7

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25 February 2020

language of work or name

English

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publication date

1 January 2013

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25 February 2020

published in

Nature Communications

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25 February 2020

volume

4

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25 February 2020

page(s)

1551

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https://scigraph.springernature.com/pub.10.1038/ncomms2533

25 February 2020

exact match

0 references

cites work

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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Tumor suppression by Ink4a-Arf: progress and puzzles

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Divorcing ARF and p53: an unsettled case

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The Arf/p53 pathway in cancer and aging

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Stability of nucleolar versus non-nucleolar forms of human p14(ARF).

21 January 2018

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N-terminal polyubiquitination and degradation of the Arf tumor suppressor

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Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

21 January 2018

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CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein

21 January 2018

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Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis

21 January 2018

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The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1

21 January 2018

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Siva is an apoptosis-selective p53 target gene important for neuronal cell death

21 January 2018

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Suppression of p53 activity by Siva1

21 January 2018

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Multifaceted functions of Siva-1: more than an Indian God of Destruction

21 January 2018

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Growth suppression by a p14(ARF) exon 1beta adenovirus in human tumor cell lines of varying p53 and Rb status

21 January 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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E2F and Ras Synergize in Transcriptionally Activating p14ARFExpression

21 January 2018

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Human ARF binds E2F1 and inhibits its transcriptional activity.

21 January 2018

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p53-independent apoptosis is induced by the p19ARF tumor suppressor

21 January 2018

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Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

21 January 2018

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p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice

21 January 2018

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Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

21 January 2018

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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

21 January 2018

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RUVBL2 is a novel repressor of ARF transcription

21 January 2018

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p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb

21 January 2018

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Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

21 January 2018

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Ink4-Arf locus in cancer and aging

21 January 2018

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Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules

21 January 2018

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The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis

21 January 2018

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

21 January 2018

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Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element

21 January 2018

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p19ARF links the tumour suppressor p53 to Ras

21 January 2018

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Human tumor suppressor ARF impedes S-phase progression independent of p53

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23462994

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS2533

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23462994%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

0 references

release_ix4owl4mynebllz6jq7g3l62p4

0 references

1 reference

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