Iron and ferroptosis: A still ill-defined liaison (Q39169905)

9 September 2017

Iron and ferroptosis: A still ill-defined liaison (English)

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9 September 2017

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Marcus Conrad

2

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author name string

Sebastian Doll

series ordinal

1

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9 September 2017

9 March 2017

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9 September 2017

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9 September 2017

69

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9 September 2017

6

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9 September 2017

423-434

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

9 September 2017

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

21 January 2018

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Ferroptosis: an iron-dependent form of nonapoptotic cell death

21 January 2018

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Regulation of ferroptotic cancer cell death by GPX4

21 January 2018

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

21 January 2018

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Regulated necrosis: disease relevance and therapeutic opportunities

21 January 2018

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Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

21 January 2018

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Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

21 January 2018

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Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

21 January 2018

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Role of membrane transport in metabolism and function of glutathione in mammals

21 January 2018

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The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond

21 January 2018

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Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein

21 January 2018

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CATs and HATs: the SLC7 family of amino acid transporters

21 January 2018

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Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.

21 January 2018

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Interaction of L-cysteine with a human excitatory amino acid transporter

21 January 2018

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Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance

21 January 2018

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Growth factors and vitamin E modify neuronal glutamate toxicity

21 January 2018

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A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

21 January 2018

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Oxytosis: A novel form of programmed cell death

21 January 2018

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Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

21 January 2018

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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

21 January 2018

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

21 January 2018

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Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity

21 January 2018

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Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

21 January 2018

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

21 January 2018

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Emerging roles for lipids in non-apoptotic cell death

21 January 2018

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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

21 January 2018

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.

21 January 2018

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Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

21 January 2018

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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

21 January 2018

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

21 January 2018

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Ferroptosis is an autophagic cell death process

21 January 2018

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Glutaminolysis and Transferrin Regulate Ferroptosis

21 January 2018

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The ferritins: molecular properties, iron storage function and cellular regulation

21 January 2018

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Autophagy promotes ferroptosis by degradation of ferritin

21 January 2018

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An essential role for functional lysosomes in ferroptosis of cancer cells.

21 January 2018

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Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

21 January 2018

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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

21 January 2018

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Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function

21 January 2018

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Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

21 January 2018

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Ferroptosis as a p53-mediated activity during tumour suppression

21 January 2018

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System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency

21 January 2018

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Biologic and pharmacologic regulation of mammalian glutathione synthesis

21 January 2018

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Cellular glutathione and thiols metabolism.

21 January 2018

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Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana

21 January 2018

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Elucidating Compound Mechanism of Action by Network Perturbation Analysis.

21 January 2018

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Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks

21 January 2018

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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.

21 January 2018

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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

21 January 2018

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Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

21 January 2018

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Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons

21 January 2018

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Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

21 January 2018

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Glutathione peroxidase 4 is required for maturation of photoreceptor cells

21 January 2018

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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

21 January 2018

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Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice

21 January 2018

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Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

21 January 2018

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Iron toxicity and oxygen radicals

21 January 2018

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Oxygen-derived species: their relation to human disease and environmental stress

21 January 2018

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Generation of superoxide by the mitochondrial Complex I.

21 January 2018

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The labile iron pool: characterization, measurement, and participation in cellular processes(1).

21 January 2018

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Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

21 January 2018

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

21 January 2018

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The role of iron and reactive oxygen species in cell death

21 January 2018

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C11-BODIPY(581/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology

21 January 2018

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Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation

21 January 2018

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Mechanisms for the autoxidation of polyunsaturated lipids

21 January 2018

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Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids

21 January 2018

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The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate

21 January 2018

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The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis

21 January 2018

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The real radical generator other than main-product hydroperoxide in lipid autoxidation.

21 January 2018

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Chemistry and biochemistry of lipid peroxidation products.

21 January 2018

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Mammalian lipoxygenases and their biological relevance

21 January 2018

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Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase.

21 January 2018

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Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

21 January 2018

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Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection

21 January 2018

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Membrane oxidation assay--a novel lipoxygenase-based evaluation of membrane oxidizability.

21 January 2018

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Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids

21 January 2018

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Importance of lipid metabolism for intracellular and mitochondrial membrane fusion/fission processes

21 January 2018

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Roles of phosphatidylethanolamine and of its several biosynthetic pathways in Saccharomyces cerevisiae

21 January 2018

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Regulation of aminophospholipid asymmetry in murine fibroblast plasma membranes by choline and ethanolamine analogues

21 January 2018

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A subfamily of P-type ATPases with aminophospholipid transporting activity

21 January 2018

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Import of phosphatidylserine to and export of phosphatidylethanolamine molecular species from mitochondria

21 January 2018

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Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study.

21 January 2018

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Systems analysis of protein modification and cellular responses induced by electrophile stress

21 January 2018

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4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest.

21 January 2018

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Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.

21 January 2018

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Cell signalling by reactive lipid species: new concepts and molecular mechanisms

21 January 2018

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Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation

21 January 2018

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Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells

21 January 2018

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Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice

21 January 2018

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4-Hydroxynonenal in the pathomechanisms of oxidative stress

21 January 2018

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Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

21 January 2018

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Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1616

1 reference

9 September 2017

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PubMed ID

28276141