Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission (Q39157775)

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scientific article published on November 2016

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English	Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission	scientific article published on November 2016

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scholarly article

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Europe PubMed Central

9 September 2017

Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission (English)

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9 September 2017

Jakob B. Sørensen

7

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15 May 2020

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Keimpe D Wierda

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Jörg Malsam

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Andrea Scheutzow

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Thomas H Söllner

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1 November 2016

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Journal of Neuroscience

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11865-11880

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describes a project that uses

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Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

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The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin I functions as a calcium regulator of release probability

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https://pubmed.ncbi.nlm.nih.gov/27881774

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inferred from PubMed ID database lookup

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

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https://pubmed.ncbi.nlm.nih.gov/27881774

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based on heuristic

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Short-term synaptic plasticity

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https://pubmed.ncbi.nlm.nih.gov/27881774

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Three-dimensional structure of the complexin/SNARE complex

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https://pubmed.ncbi.nlm.nih.gov/27881774

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based on heuristic

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Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

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Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I.

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin mutants Y311N and K326/327A alter the calcium dependence of neurotransmission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

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Conserved prefusion protein assembly in regulated exocytosis

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release

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https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

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Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison between exocytic control mechanisms in adrenal chromaffin cells and a glutamatergic synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

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Differential Abilities of SNAP-25 Homologs to Support Neuronal Function

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dual-Ca2+-sensor model for neurotransmitter release in a central synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

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Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

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Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

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Distinctive quantal properties of neurotransmission at excitatory and inhibitory autapses revealed using variance-mean analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing functions of two sub-domains of the SNARE-complex in neurotransmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated analysis of neuronal morphology, synapse number and synaptic recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin increases the dynamic range of synapses by driving Ca²+-evoked release and by clamping a near-linear remaining Ca²+ sensor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular machines governing exocytosis of synaptic vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotransmitter release: the last millisecond in the life of a synaptic vesicle

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innervation by a GABAergic Neuron Depresses Spontaneous Release in Glutamatergic Neurons and Unveils the Clamping Phenotype of Synaptotagmin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Re-examining how complexin inhibits neurotransmitter release

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How could SNARE proteins open a fusion pore?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Synaptic Vesicle Release Machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different states of synaptotagmin regulate evoked versus spontaneous release

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect on synaptic physiology of synaptotagmin mutations in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of synaptotagmin-binding domains on syntaxin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Definition of the readily releasable pool of vesicles at hippocampal synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of release probability, facilitation, and depletion at central synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+-dependent and -independent interactions of the isoforms of the alpha1A subunit of brain Ca2+ channels with presynaptic SNARE proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SNAREpins: minimal machinery for membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881774

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1011-16.2016

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6604916&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6604916&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6604916&resulttype=core&format=json

15 May 2020

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