Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release (Q36137565)

12 August 2017

Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release (English)

1 reference

12 August 2017

Jörg Malsam

1

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12 August 2017

Daniel Parisotto

2

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12 August 2017

Tanmay A M Bharat

3

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12 August 2017

Andrea Scheutzow

4

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12 August 2017

Jean Michel Krause

5

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12 August 2017

John A G Briggs

6

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12 August 2017

Thomas H Söllner

7

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12 August 2017

language of work or name

English

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publication date

15 June 2012

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12 August 2017

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12 August 2017

31

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12 August 2017

15

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12 August 2017

3270-3281

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3411073/fullTextXML

inferred from PubMed Central ID database lookup

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Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

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Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix

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Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

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Alternative zippering as an on-off switch for SNARE-mediated fusion

2 October 2017

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Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.

2 October 2017

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Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming.

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Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

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Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.

2 October 2017

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2 October 2017

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2 October 2017

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How does synaptotagmin trigger neurotransmitter release?

2 October 2017

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2 October 2017

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C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo.

2 October 2017

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2 October 2017

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A clamping mechanism involved in SNARE-dependent exocytosis

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Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release

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2 October 2017

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Structurally and functionally unique complexins at retinal ribbon synapses

2 October 2017

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Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain

2 October 2017

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The synaptic vesicle cycle

2 October 2017

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Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate

2 October 2017

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Fusion of cells by flipped SNAREs

2 October 2017

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Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells

2 October 2017

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Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

2 October 2017

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Three-dimensional structure of the complexin/SNARE complex

2 October 2017

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Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities

2 October 2017

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Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

2 October 2017

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Synaptotagmins: why so many?

2 October 2017

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Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

2 October 2017

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Synaptotagmin I functions as a calcium regulator of release probability

2 October 2017

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Complexins regulate a late step in Ca2+-dependent neurotransmitter release

2 October 2017

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The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes

2 October 2017

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Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

2 October 2017

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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

2 October 2017

1 reference

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SNAREpins: minimal machinery for membrane fusion

2 October 2017

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Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

2 October 2017

1 reference

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SNAP receptors implicated in vesicle targeting and fusion

2 October 2017

1 reference

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Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Calcium dependence of the rate of exocytosis in a synaptic terminal

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Complexins: cytosolic proteins that regulate SNAP receptor function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Use of resonance energy transfer to monitor membrane fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin perturbs the structure of phospholipid bilayers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I.

2 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

A role for synaptotagmin (p65) in regulated exocytosis

2 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

CHELATOR: an improved method for computing metal ion concentrations in physiological solutions.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.

2 July 2018

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Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms

21 January 2018

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The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).

21 January 2018

1 reference

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Reconstitution of depolarization and Ca2+-evoked secretion in Xenopus oocytes monitored by membrane capacitance.

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Drosophila synaptotagmin I null mutants show severe alterations in vesicle populations but calcium-binding motif mutants do not.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Distinct domains of complexin I differentially regulate neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Mutations in the second C2 domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctions

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

23 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Real-time measurement of transmitter release from single synaptic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion

21 January 2018

1 reference

12 December 2020

N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane Fusion

1 reference

12 December 2020

Energetics and dynamics of SNAREpin folding across lipid bilayers

1 reference

12 December 2020

Activity-dependent changes in partial VAMP complexes during neurotransmitter release

1 reference

12 December 2020

Transfection analysis of functional roles of complexin I and II in the exocytosis of two different types of secretory vesicles

1 reference

12 December 2020

Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2012.164

1 reference

12 August 2017

1 reference

12 August 2017

1 reference