Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease (Q39154570)

9 September 2017

title

Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease (English)

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9 September 2017

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Bing Li

1

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9 September 2017

Dawei Yu

series ordinal

2

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9 September 2017

Zhiying Xu

series ordinal

3

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9 September 2017

publication date

10 May 2013

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Journal of Molecular Neuroscience

9 September 2017

published in

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9 September 2017

volume

51

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9 September 2017

issue

2

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9 September 2017

page(s)

539-549

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https://scigraph.springernature.com/pub.10.1007/s12031-013-0022-8

9 September 2017

exact match

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cites work

Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Parkinson disease: insights in clinical, genetic and pathological features of monogenic disease subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Parkinson disease: from pathology to molecular disease mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

DJ-1 decreases Bax expression through repressing p53 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Parkinson's disease. First of two parts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Molecular pathophysiology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Toxic proteins released from mitochondria in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

A randomized controlled clinical trial to compare the safety and efficacy of edaravone in acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Effects of edaravone on reperfusion injury in patients with acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Assessment of cell viability in primary neuronal cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-0022-8

Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23657982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-term efficacy of edaravone in patients with acute myocardial infarction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23657982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23657982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S12031-013-0022-8

1 reference

9 September 2017

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