Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia (Q39105456)

9 September 2017

Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia (English)

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9 September 2017

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D Allegra

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9 September 2017

V Bilan

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A Garding

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H Döhner

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S Stilgenbauer

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F Kuchenbauer

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D Mertens

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M Zucknick

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9 September 2017

26 August 2013

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28

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98-107

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https://scigraph.springernature.com/pub.10.1038/leu.2013.246

9 September 2017

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Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

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Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia

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Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism

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Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization

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Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions.

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Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)

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DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse

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DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

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The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia

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Widespread microRNA repression by Myc contributes to tumorigenesis

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

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Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice

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TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q.

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The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

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DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs

21 January 2018

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Efficient nucleofection of primary human B cells and B-CLL cells induces apoptosis, which depends on the microenvironment and on the structure of transfected nucleic acids

21 January 2018

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Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo

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Impaired microRNA processing enhances cellular transformation and tumorigenesis

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Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

21 January 2018

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Dynamic association of RNA-editing enzymes with the nucleolus

21 January 2018

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Adenosine deaminases acting on RNA, RNA editing, and interferon action.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.246

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.246

Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma

21 January 2018

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12 December 2020

Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping

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12 December 2020

Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations

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12 December 2020

Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells

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12 December 2020

Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from peripheral blood

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12 December 2020

TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations

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12 December 2020

In-vivo quantification of primary microRNA processing by Drosha with a luciferase based system

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12 December 2020

Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines

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12 December 2020

CLL and deletion 13q14: merely the miRs?

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12 December 2020

Modeling tumor-host interactions of chronic lymphocytic leukemia in xenografted mice to study tumor biology and evaluate targeted therapy

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12 December 2020

Functional evidence that Drosha overexpression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles

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12 December 2020

Short structured RNAs with low GC content are selectively lost during extraction from a small number of cells

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12 December 2020

BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma

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12 December 2020

Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes

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12 December 2020

Identifiers

DOI

10.1038/LEU.2013.246

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Dimensions Publication ID

9 September 2017

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