Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase (Q39035366)

8 September 2017

Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase (English)

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8 September 2017

C Xu

1

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8 September 2017

C D Fan

series ordinal

2

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8 September 2017

X Wang

series ordinal

3

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8 September 2017

language of work or name

English

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publication date

13 January 2014

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8 September 2017

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8 September 2017

34

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8 September 2017

3

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8 September 2017

281-289

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https://scigraph.springernature.com/pub.10.1038/onc.2013.557

8 September 2017

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cites work

The first 30 years of p53: growing ever more complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

The p53 orchestra: Mdm2 and Mdmx set the tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

MDM2 and Ki-67 predict for distant metastasis and mortality in men treated with radiotherapy and androgen deprivation for prostate cancer: RTOG 92-02.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

p53 Activation by nitric oxide involves down-regulation of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

The ubiquitin-proteasome pathway: on protein death and cell life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Nonproteolytic functions of ubiquitin in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Regulation of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Role of histone H2A ubiquitination in Polycomb silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy

21 January 2018

1 reference

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Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.557

Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24413081

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24413081

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2013.557

1 reference

Dimensions Publication ID

8 September 2017

1026173806

0 references

Fatcat ID

release_ywkoyrmtnbhz3hgpollc7ouzm4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ywkoyrmtnbhz3hgpollc7ouzm4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference