Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends (Q39022532)

8 September 2017

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends (English)

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8 September 2017

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3

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8 September 2017

Sergey O Bachurin

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PubMed ID

28084618

8 September 2017

Elena V Bovina

series ordinal

2

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8 September 2017

13 January 2017

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Medicinal Research Reviews

8 September 2017

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8 September 2017

37

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8 September 2017

1186-1225

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8 September 2017

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Alzheimer's disease drug-development pipeline: few candidates, frequent failures

8 September 2017

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[Molecular aspects of the pathogenesis and current approaches to pharmacological correction of Alzheimer's disease].

21 January 2018

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Alzheimer disease: a tale of two prions

21 January 2018

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The multifactorial nature of Alzheimer's disease for developing potential therapeutics.

21 January 2018

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

21 January 2018

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The revitalized tau hypothesis on Alzheimer's disease

21 January 2018

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What causes alzheimer's disease?

21 January 2018

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21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.

21 January 2018

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A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

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Function and dysfunction of the presenilins

21 January 2018

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

21 January 2018

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Structural characterization of the core of the paired helical filament of Alzheimer disease

21 January 2018

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CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

21 January 2018

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Alzheimer's disease: a central role for amyloid

21 January 2018

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Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

21 January 2018

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A beta oligomers - a decade of discovery

21 January 2018

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21 January 2018

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Mitochondrial dysfunction: cause and consequence of Alzheimer's disease

21 January 2018

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Neurobiology of Alzheimer's Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions

21 January 2018

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Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

21 January 2018

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Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease

21 January 2018

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Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer's disease.

21 January 2018

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Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease--a unified glutamatergic hypothesis on the mechanism of action.

21 January 2018

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Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections

21 January 2018

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Neurobiology of Alzheimer's disease

21 January 2018

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Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor

21 January 2018

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Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

21 January 2018

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Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.

21 January 2018

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18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease.

21 January 2018

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Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

21 January 2018

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Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing

21 January 2018

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Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases

21 January 2018

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Site-specific UBITh amyloid-beta vaccine for immunotherapy of Alzheimer's disease

21 January 2018

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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

21 January 2018

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Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study.

21 January 2018

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Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial

21 January 2018

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

21 January 2018

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A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

21 January 2018

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Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans

21 January 2018

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Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01

21 January 2018

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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

21 January 2018

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Transthyretin amyloidoses: New strategies for therapeutic intervention

21 January 2018

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Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

21 January 2018

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Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders

21 January 2018

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Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

21 January 2018

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Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

21 January 2018

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Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease

21 January 2018

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21 January 2018

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Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status.

21 January 2018

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Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial

21 January 2018

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SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study.

21 January 2018

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Nicotinic Acetylcholine Receptors in the Pathophysiology of Al zheimer's Disease: The Role of Protein-Protein Interactions in Current and Future Treatment

21 January 2018

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Glutamate transmission and toxicity in Alzheimer's disease

21 January 2018

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Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases

21 January 2018

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Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy

21 January 2018

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Benzoate, a D-amino acid oxidase inhibitor, for the treatment of early-phase Alzheimer disease: a randomized, double-blind, placebo-controlled trial

21 January 2018

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21 January 2018

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Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial

21 January 2018

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Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

21 January 2018

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Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments

21 January 2018

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Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.

21 January 2018

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The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis

21 January 2018

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Long-term treatment with L-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease.

21 January 2018

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Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

21 January 2018

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Levetiracetam might act as an efficacious drug to attenuate cognitive deficits of Alzheimer's disease

21 January 2018

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Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression

21 January 2018

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Systemic administration of riluzole enhances recognition memory and facilitates extinction of fear memory in rats.

21 January 2018

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The glutamate hypothesis in ALS: pathophysiology and drug development.

21 January 2018

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Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype

21 January 2018

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Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice.

21 January 2018

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Amyloid-cholinesterase interactions. Implications for Alzheimer's disease

21 January 2018

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Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice

21 January 2018

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Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment

21 January 2018

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Effect of long-term treatment with rasagiline on cognitive deficits and related molecular cascades in aged mice.

21 January 2018

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Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials

21 January 2018

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Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile x mice

21 January 2018

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Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system.

21 January 2018

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Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats

21 January 2018

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Effects of the neurotrophic agent T-817MA on oligomeric amyloid-β-induced deficits in long-term potentiation in the hippocampal CA1 subfield

21 January 2018

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Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

21 January 2018

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NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport.

21 January 2018

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Tolerability, safety and pharmacokinetics of the FGLL peptide, a novel mimetic of neural cell adhesion molecule, following intranasal administration in healthy volunteers.

21 January 2018

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Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease

21 January 2018

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Medication use in a large international sample of people with multiple sclerosis: associations with quality of life, relapse rate and disability

21 January 2018

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Randomized, Placebo-Controlled, Phase III Trial of Yeast-Derived Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus Peptide Vaccination Versus GM-CSF Plus Peptide Vaccination Versus Placebo in Patients With No Evidence of Disease After

21 January 2018

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Sargramostim (GM-CSF) and lenalidomide in castration-resistant prostate cancer (CRPC): results from a phase I-II clinical trial

21 January 2018

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The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function

21 January 2018

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Targeting neuroinflammation in Alzheimer's disease: evidence for NSAIDs and novel therapeutics

21 January 2018

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Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

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Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

21 January 2018

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Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25-35-induced memory impairment and oxidative stress in mice.

21 January 2018

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Neuroprotective effect of epigallocatechin-3-gallate in a mouse model of chronic glaucoma.

21 January 2018

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Ginkgo Biloba for Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

21 January 2018

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Resveratrol, a neuroprotective supplement for Alzheimer's disease.

21 January 2018

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A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

21 January 2018

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Syntheses And Evaluation Of Asymmetric Curcumin Analogues As Potential Multifunctional Agents For The Treatment Of Alzheimer's Disease

21 January 2018

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Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimer's disease.

21 January 2018

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Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors.

21 January 2018

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Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose

21 January 2018

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Lack of support for bexarotene as a treatment for Alzheimer's disease

21 January 2018

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

21 January 2018

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Tamibarotene: a candidate retinoid drug for Alzheimer's disease

21 January 2018

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Influence of isotretinoin on hippocampal-based learning in human subjects

21 January 2018

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Retinoids for treatment of Alzheimer's disease

21 January 2018

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Cognitive effects of statin medications

21 January 2018

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Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin

21 January 2018

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Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease.

21 January 2018

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Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.

21 January 2018

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A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

21 January 2018

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Statins for Treating Alzheimer's Disease: Truly Ineffective?

21 January 2018

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Therapeutic strategies for Alzheimer's disease in clinical trials.

21 January 2018

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Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.

21 January 2018

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An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease.

21 January 2018

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Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease.

21 January 2018

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Advances in Psychopharmacology for Anxiety Disorders

21 January 2018

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Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer's Disease?

21 January 2018

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New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

21 January 2018

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Drug repositioning for Alzheimer's disease.

21 January 2018

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Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

21 January 2018

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Developing pharmacological therapies for Alzheimer disease

21 January 2018

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The Potential of Proteomics in Understanding Neurodegeneration.

21 January 2018

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Alzheimer's disease: clinical trials and drug development

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.21434

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8 September 2017

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PubMed ID

28084618