Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease (Q26739412)

PubMed

17 September 2019

cytoskeletal proteins

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11 December 2019

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29 April 2021

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Madia Lozupone

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Andrea Santamato

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Chiara Zecca

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Maria Rosaria Barulli

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Antonello Bellomo

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Alberto Pilotto

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Antonio Daniele

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Antonio Greco

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BioMed Research International

10 June 2020

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26 June 2016

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25 April 2019

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11 December 2019

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2016

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Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Dimethyl fumarate : a Janus-faced substance?

28 September 2017

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Methylene blue induces macroautophagy through 5' adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation

28 September 2017

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"Prion-like" templated misfolding in tauopathies

28 September 2017

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Progress and developments in tau aggregation inhibitors for Alzheimer disease

28 September 2017

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Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

28 September 2017

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Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.

28 September 2017

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Tau protein kinases: involvement in Alzheimer's disease

28 September 2017

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Structure and pathology of tau protein in Alzheimer disease

28 September 2017

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The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice

28 September 2017

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Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies.

28 September 2017

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Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate.

28 September 2017

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Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

28 September 2017

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Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43.

28 September 2017

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Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.

28 September 2017

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

28 September 2017

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The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

28 September 2017

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"Lest we forget you--methylene blue...".

28 September 2017

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Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

28 September 2017

1 reference

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Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

28 September 2017

1 reference

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Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease

28 September 2017

1 reference

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Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss

28 September 2017

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Acetylation of tau inhibits its degradation and contributes to tauopathy

28 September 2017

1 reference

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Tau in Alzheimer disease and related tauopathies

28 September 2017

1 reference

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TAU Aggregation is a Therapeutic Target for Alzheimers Disease

28 September 2017

1 reference

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Tau protein and tau aggregation inhibitors

28 September 2017

1 reference

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Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Towards disease-modifying treatment of Alzheimer's disease: drugs targeting beta-amyloid.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Structure-activity relationship of cyanine tau aggregation inhibitors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Propagation of tau misfolding from the outside to the inside of a cell.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Rhodanine-based tau aggregation inhibitors in cell models of tauopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Assembly of two distinct dimers and higher-order oligomers from full-length tau.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Small molecule inhibitors of alpha-synuclein filament assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

The phenothiazinium chromophore and the evolution of antimalarial drugs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Glycogen synthase kinase 3: a drug target for CNS therapies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Evolution of the neuropathology of Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

"Clicked" sugar-curcumin conjugate: modulator of amyloid-β and tau peptide aggregation at ultralow concentrations

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Chemical manipulation of hsp70 ATPase activity regulates tau stability.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Frequency of stages of Alzheimer-related lesions in different age categories

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

The interaction between methylene blue and the cholinergic system

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Stimulation of respiration by methylene blue in rat liver mitochondria.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Human secreted tau increases amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Modulation of tau protein fibrillization by oleocanthal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Inhibition of tau filament formation by conformational modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and B6C3F1 mouse urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Pharmacokinetics and organ distribution of intravenous and oral methylene blue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Inhibition of nitric oxide synthesis by methylene blue

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Adverse effects of methylene blue on the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer's Disease Mouse Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Methylene blue inhibits the function of α7-nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

The crystalline state of methylene blue: a zoo of hydrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3245935

Pharmacological evidence that methylene blue inhibits noradrenaline neuronal uptake in the rat vas deferens.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Methylene blue supravital staining: an evaluation of its applicability to the mammalian brain and pineal gland

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4939203

Color and constitution: one hundred years of research

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27429978

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Paired helical filament-like phosphorylation of tau, deposition of beta/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27429978

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2016/3245935

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27429978%20AND%20SRC:MED&resulttype=core&format=json

release_io4garc7unb6rf4o6e3n6fjfs4

10 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/io4garc7unb6rf4o6e3n6fjfs4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27429978%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

27429978

2 references