Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis (Q39000961)

8 September 2017

Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis (English)

1 reference

8 September 2017

4

1 reference

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1 June 2020

author name string

S C Cazanave

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769730%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

X Wang

2

1 reference

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1 June 2020

H Zhou

3

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1 June 2020

S Grant

5

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1 June 2020

D E Durrant

6

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1 June 2020

C D Klaassen

7

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1 June 2020

M Yamamoto

8

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1 June 2020

A J Sanyal

9

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1 June 2020

publication date

25 April 2014

1 reference

Cell Death & Differentiation

8 September 2017

1 reference

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1 June 2020

volume

21

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1 June 2020

issue

8

1 reference

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1 June 2020

page(s)

1303-1312

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769730%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/cdd.2014.49

1 June 2020

exact match

0 references

cites work

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9 September 2017

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Keap1 degradation by autophagy for the maintenance of redox homeostasis

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

9 September 2017

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Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis

9 September 2017

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Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

9 September 2017

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Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation

9 September 2017

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Death receptor 5 signaling promotes hepatocyte lipoapoptosis

9 September 2017

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Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes

9 September 2017

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Autophagy in nonalcoholic steatohepatitis

9 September 2017

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INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

9 September 2017

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Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

9 September 2017

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Genetic analysis of cytoprotective functions supported by graded expression of Keap1

9 September 2017

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

9 September 2017

1 reference

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Mcl-1 degradation during hepatocyte lipoapoptosis

9 September 2017

1 reference

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Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

9 September 2017

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JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis

9 September 2017

1 reference

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Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

9 September 2017

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The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

9 September 2017

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Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

9 September 2017

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The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

9 September 2017

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Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

9 September 2017

1 reference

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Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

9 September 2017

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Bax inhibition protects against free fatty acid-induced lysosomal permeabilization

9 September 2017

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9 September 2017

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Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

9 September 2017

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

9 September 2017

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

9 September 2017

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9 September 2017

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9 September 2017

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

9 September 2017

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Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line

9 September 2017

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Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

14 September 2017

1 reference

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Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis

14 September 2017

1 reference

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Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

Unbound free fatty acid levels in human serum.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

Hormonal regulation of cholesterol 7 alpha-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures

17 June 2018

1 reference

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Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085536

Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis

21 August 2018

1 reference

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Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in JCR:LA-cp rats.

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FCDD.2014.49

Non-alcoholic fatty liver disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24769730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24769730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24769730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDD.2014.49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769730%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769730%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769730%20AND%20SRC:MED&resulttype=core&format=json