Genetic analysis of cytoprotective functions supported by graded expression of Keap1 (Q33877576)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

Genetic analysis of cytoprotective functions supported by graded expression of Keap1 (English)

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31 January 2020

3

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31 January 2020

author name string

Keiko Taguchi

1

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31 January 2020

Jonathan M Maher

2

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31 January 2020

Yukie Kawatani

4

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31 January 2020

Hozumi Motohashi

5

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31 January 2020

Masayuki Yamamoto

6

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31 January 2020

language of work or name

English

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publication date

19 April 2010

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Molecular and Cellular Biology

31 January 2020

published in

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31 January 2020

volume

30

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31 January 2020

page(s)

3016-3026

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31 January 2020

issue

12

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Stress-activated cap'n'collar transcription factors in aging and human disease

31 January 2020

cites work

1 reference

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

28 July 2018

1 reference

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KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta

28 July 2018

1 reference

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Nrf2: friend or foe for chemoprevention?

28 July 2018

1 reference

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

28 July 2018

1 reference

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

28 July 2018

1 reference

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Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

28 July 2018

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Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

28 July 2018

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

28 July 2018

1 reference

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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

28 July 2018

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Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

28 July 2018

1 reference

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Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

28 July 2018

1 reference

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Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

28 July 2018

1 reference

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Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression.

28 July 2018

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Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing

28 July 2018

1 reference

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Nrf2-Keap1 defines a physiologically important stress response mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

28 July 2018

1 reference

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

28 July 2018

1 reference

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

28 July 2018

1 reference

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

28 July 2018

1 reference

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Regulation of glutathione synthesis.

28 July 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

28 July 2018

1 reference

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

28 July 2018

1 reference

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Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

28 July 2018

1 reference

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

28 July 2018

1 reference

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28 July 2018

1 reference

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Sites of alkylation of human Keap1 by natural chemoprevention agents

29 October 2018

1 reference

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Subcellular localization and cytoplasmic complex status of endogenous Keap1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677

29 October 2018

Identifiers

DOI

10.1128/MCB.01591-09

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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31 January 2020

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