Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model. (Q38991133)

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English	Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.	scientific article

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Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model (English)

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Alzheimer's disease

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Zhong-Hao Zhang

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Qiu-Yan Wu

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Rui Zheng

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Chen Chen

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Yao Chen

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Peter R Hoffmann

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Jia-Zuan Ni

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30 January 2017

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Journal of Neuroscience

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2449-2462

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10 April 2020

TOR, a central controller of cell growth

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Autophagy as a regulated pathway of cellular degradation

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Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

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Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice

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https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Tau suppression in a neurodegenerative mouse model improves memory function

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P70 S6 kinase mediates tau phosphorylation and synthesis

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation

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[Role of serine/threonine protein phosphatase in tau phosphorylation]

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Oxidative stress and Alzheimer disease: the autophagy connection?

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

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Cathepsin D expression is decreased in Alzheimer's disease fibroblasts

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Selenium level and cognitive function in rural elderly Chinese

1 reference

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Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

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Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis

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https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

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Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

1 reference

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

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Autophagy fights disease through cellular self-digestion

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

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https://pubmed.ncbi.nlm.nih.gov/28137967

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The role of tau in neurodegeneration

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Selenium attenuates A beta production and A beta-induced neuronal death.

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Methods in mammalian autophagy research

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

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https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Convergence of amyloid-beta and tau pathologies on mitochondria in vivo

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Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

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12 December 2020

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A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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The role of tau kinases in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Tau reduction prevents Abeta-induced defects in axonal transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

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Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

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https://pubmed.ncbi.nlm.nih.gov/28137967

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Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease.

1 reference

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12 December 2020

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Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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GSK3 and tau: two convergence points in Alzheimer's disease.

1 reference

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12 December 2020

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Selenium level and depressive symptoms in a rural elderly Chinese cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

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https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Soluble forms of tau are toxic in Alzheimer's disease

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12 December 2020

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Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells

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Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

1 reference

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12 December 2020

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Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches

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12 December 2020

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Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Selenomethionine ameliorates cognitive decline, reduces tau hyperphosphorylation, and reverses synaptic deficit in the triple transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Protein phosphatase 2A dysfunction in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Ischemic preconditioning provides neuroprotection by induction of AMP-activated protein kinase-dependent autophagy in a rat model of ischemic stroke.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Effect size of memory deficits in mice with adult-onset P301L tau expression

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12 December 2020

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Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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The physiology and pathology of microtubule-associated protein tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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BACE1 RNA interference improves spatial memory and attenuates Aβ burden in a streptozotocin-induced tau hyperphosphorylated rat model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

1 reference

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12 December 2020

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Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Cyclin-Dependent kinase 5 targeting prevents β-Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox regulation of autophagy in healthy brain and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Autophagy in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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2015 Alzheimer's disease facts and figures

1 reference

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Loss of tau rescues inflammation-mediated neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

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The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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The Role of Oxidative Stress in Neurodegenerative Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Degradation of proteasomes by lysosomes in rat liver.

1 reference

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12 December 2020

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

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12 December 2020

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Identifiers

10.1523/JNEUROSCI.3229-16.2017

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10 April 2020

1 reference

Europe PubMed Central

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