Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development. (Q38963912)

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scientific article published on 22 August 2014

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English	Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development.	scientific article published on 22 August 2014

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13 March 2020

Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development (English)

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Anastasia Spyropoulou

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Angelica A Saetta

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Georgia Levidou

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Eleni-Andriana Trigka

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Joanna Sakalidou

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Christina Piperi

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Ilenia Chatziandreou

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Rigas Soldatos

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Georgia Tomara

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Kalliopi Petraki

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Vassilis Samaras

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Athanasios Zisakis

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Vassilis Varsos

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George Vrettakos

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Efstathios Boviatsis

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Efstratios Patsouris

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Penelope Korkolopoulou

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22 August 2014

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Virchows Archiv

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13 March 2020

https://scigraph.springernature.com/pub.10.1007/s00428-014-1641-3

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Histological classification and molecular genetics of meningiomas

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Molecular alterations in meningiomas: association with clinical data

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Genetic changes with prognostic value in histologically benign meningiomas

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PI3K pathway alterations in cancer: variations on a theme

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The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.

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Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy

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PI3K and STAT3: a new alliance.

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NOTCH and PI3K-AKT pathways intertwined.

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HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

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Rare cancer-specific mutations in PIK3CA show gain of function

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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

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PTEN regulation of ERK1/2 signaling in cancer

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A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

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4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis

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Radiotherapy for atypical meningiomas.

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New insights into meningioma: from genetics to trials

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Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas.

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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

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Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO

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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

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Hormone receptors in non-malignant meningiomas correlate with apoptosis, cell proliferation and recurrence-free survival

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21 January 2018

Low-level amplification of oncogenes correlates inversely with age for patients with nontypical meningiomas.

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Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway.

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Evidence for phosphatidylinositol 3-kinase-Akt-p7S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in meningioma cells

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Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas

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mTORC1 inhibitors suppress meningioma growth in mouse models

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AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.

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Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas

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The functions and regulation of the PTEN tumour suppressor

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12 December 2020

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mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

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Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions

1 reference

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12 December 2020

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Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rare mutation of PIK3CA in meningiomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

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based on heuristic

inferred from PubMed ID database lookup

Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25146167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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