Mitochondrial quality control by the Pink1/Parkin system (Q38944334)

7 September 2017

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title

Mitochondrial quality control by the Pink1/Parkin system (English)

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7 September 2017

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Cornelia Rüb

1

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7 September 2017

Anne Wilkening

series ordinal

2

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7 September 2017

Wolfgang Voos

series ordinal

3

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7 September 2017

2 September 2016

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7 September 2017

Cell and Tissue Research

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7 September 2017

367

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7 September 2017

1

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7 September 2017

111-123

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https://scigraph.springernature.com/pub.10.1007/s00441-016-2485-8

7 September 2017

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cites work

PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The pathways of mitophagy for quality control and clearance of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Ubiquitin: same molecule, different degradation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Upregulation of human PINK1 gene expression by NFκB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Oxidative stress and neurodegeneration: where are we now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The mitochondrial UPR - protecting organelle protein homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The molecular mechanism of mitochondria autophagy in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Genetics of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Restriction of trophic factors and nutrients induces PARKIN expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Characterization of PINK1 processing, stability, and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial dynamics and mitochondrial quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Oxidative stress and regulation of Pink1 in zebrafish (Danio rerio)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitonuclear communication in homeostasis and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Biochemical properties of the kinase PINK1 as sensor protein for mitochondrial damage signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Unlocking the presequence import pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondria and cell death: outer membrane permeabilization and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Structure of parkin reveals mechanisms for ubiquitin ligase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Chaperone-protease networks in mitochondrial protein homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondria removal by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Structure of the human Parkin ligase domain in an autoinhibited state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Parkin and mitochondrial quality control: toward assembling the puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Autophagy machinery in the context of mammalian mitophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Mitochondrial fission, fusion, and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

21 January 2018

Mechanisms of mitophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Pink1, the first ubiquitin kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

The kinase domain of mitochondrial PINK1 faces the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00441-016-2485-8

10.1007/S00441-016-2485-8

21 January 2018

Identifiers

DOI

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Dimensions Publication ID

7 September 2017

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1 reference