Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. (Q38923789)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18204048%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal (English)

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6

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1 January 2020

Amjad Javed

series ordinal

1

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8

Andre J van Wijnen

1 reference

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10

Gary S Stein

1 reference

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11

Jane B Lian

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1 January 2020

9

Janet L Stein

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1 January 2020

5

Jitesh Pratap

1 reference

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1 January 2020

4

Soraya Gutierrez

1 reference

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1 January 2020

3

Faiza Afzal

1 reference

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1 January 2020

2

Jong-Sup Bae

1 reference

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1 January 2020

author name string

Yang Lou

series ordinal

7

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1 January 2020

language of work or name

English

0 references

publication date

18 January 2008

1 reference

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Journal of Biological Chemistry

1 January 2020

published in

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volume

283

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issue

13

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1 January 2020

page(s)

8412-8422

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Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

1 January 2020

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HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.

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9 September 2017

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Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

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Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling

9 September 2017

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Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.

9 September 2017

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Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

9 September 2017

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SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation

9 September 2017

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BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype

9 September 2017

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Smad transcription factors

9 September 2017

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Runx2: a master organizer of gene transcription in developing and maturing osteoblasts

9 September 2017

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Menin and TGF-beta superfamily member signaling via the Smad pathway in pituitary, parathyroid and osteoblast

9 September 2017

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BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

9 September 2017

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SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation

9 September 2017

1 reference

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Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

9 September 2017

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BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression

9 September 2017

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Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways

9 September 2017

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Consequences of knocking out BMP signaling in the mouse

9 September 2017

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9 September 2017

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Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites

9 September 2017

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Mutations in the RUNX2 gene in patients with cleidocranial dysplasia

9 September 2017

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Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

9 September 2017

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runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins

9 September 2017

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Smad-Runx interactions during chondrocyte maturation

9 September 2017

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

9 September 2017

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A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

9 September 2017

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Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription

9 September 2017

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

9 September 2017

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

9 September 2017

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BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

9 September 2017

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Alterations in intranuclear localization of Runx2 affect biological activity

14 September 2017

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Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation

14 September 2017

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Smads oppose Hox transcriptional activities

14 September 2017

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Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription.

14 September 2017

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Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model

14 September 2017

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Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

14 September 2017

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A human Mad protein acting as a BMP-regulated transcriptional activator

25 September 2017

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Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells

25 September 2017

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Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells

17 June 2018

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BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest.

17 June 2018

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Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme

22 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18204048

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12 December 2020

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Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18204048

inferred from PubMed ID database lookup

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New concepts in tissue-specific metastases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18204048

inferred from PubMed ID database lookup

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Identifiers

DOI

10.1074/JBC.M705578200

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1 January 2020

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