Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions. (Q38902256)

7 September 2017

Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions (English)

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13 May 2020

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1

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author name string

Lauren O'Neill

2

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13 May 2020

Lizbeth M Nieves

3

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13 May 2020

Megan S McAfee

4

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13 May 2020

Susan A Holechek

5

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13 May 2020

Andrea W Collins

6

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Paul Dickman

7

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Jeffrey Jacobsen

8

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Pooja Hingorani

9

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Joseph N Blattman

10

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publication date

1 April 2015

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7 September 2017

11

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inferred from page(s)

published in

Journal of Immunotherapy

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13 May 2020

volume

38

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13 May 2020

page(s)

96-106

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issue

3

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Combined modality treatment for osteosarcoma occurring as a second malignant disease. Cooperative German-Austrian-Swiss Osteosarcoma Study Group

13 May 2020

cites work

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12 December 2020

Sequential loss of cytotoxic T lymphocyte responses to simian virus 40 large T antigen epitopes in T antigen transgenic mice developing osteosarcomas

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12 December 2020

Effect of timing of pulmonary metastases identification on prognosis of patients with osteosarcoma: the Japanese Musculoskeletal Oncology Group study

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12 December 2020

Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection.

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12 December 2020

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

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12 December 2020

Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

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12 December 2020

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

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12 December 2020

Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity

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12 December 2020

Management of osteosarcoma pulmonary metastases

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12 December 2020

PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma

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12 December 2020

Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer.

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12 December 2020

Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.

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12 December 2020

CD8 T cell dysfunction during chronic viral infection.

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12 December 2020

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.

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12 December 2020

T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival

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12 December 2020

Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy

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12 December 2020

Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma

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12 December 2020

Increased programmed death-1+ tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival

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12 December 2020

Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma

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12 December 2020

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

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12 December 2020

The epidemiology of osteosarcoma

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12 December 2020

Osteosarcoma lung metastases detection and principles of multimodal therapy

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12 December 2020

Understanding micrometastatic disease and Anoikis resistance in ewing family of tumors and osteosarcoma

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12 December 2020

B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis.

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12 December 2020

Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance

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12 December 2020

B7-H3 expression in gastric cancer: a novel molecular blood marker for detecting circulating tumor cells.

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12 December 2020

Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors

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12 December 2020

Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma

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12 December 2020

Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production

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12 December 2020

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12 December 2020

Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape

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12 December 2020

IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma

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12 December 2020

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

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12 December 2020

The expression, function, and clinical relevance of B7 family members in cancer

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12 December 2020

Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo

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12 December 2020

Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung.

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12 December 2020

Cutting edge: intravascular staining redefines lung CD8 T cell responses.

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12 December 2020

New targets and approaches in osteosarcoma.

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12 December 2020

Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma

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12 December 2020

Strength of PD-1 signaling differentially affects T-cell effector functions.

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12 December 2020

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

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12 December 2020

Nivolumab plus ipilimumab in advanced melanoma

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12 December 2020

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.

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12 December 2020

B7-H3 is overexpressed in patients suffering osteosarcoma and associated with tumor aggressiveness and metastasis

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12 December 2020

CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients

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12 December 2020

TIM-3 expression in human osteosarcoma: Correlation with the expression of epithelial-mesenchymal transition-specific biomarkers

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12 December 2020

The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer.

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12 December 2020

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

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12 December 2020

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors.

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12 December 2020

Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

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12 December 2020

Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity

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12 December 2020

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment

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12 December 2020

Programmed cell death ligand 1 expression in osteosarcoma

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12 December 2020

Cytolysis of autologous fresh osteosarcoma cells by human cytotoxic T lymphocytes propagated with T cell growth factor

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12 December 2020

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

1 reference

12 December 2020

Viral immune evasion due to persistence of activated T cells without effector function

1 reference

12 December 2020

10.1097/CJI.0000000000000065

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6426450&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6426450&resulttype=core&format=json

13 May 2020

1 reference