PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells (Q36890941)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23676462%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells (English)

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1 March 2020

5

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1 March 2020

Ben Youngblood

7

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1 March 2020

10

Rafi Ahmed

1 reference

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1 March 2020

8

Gordon J Freeman

1 reference

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1 March 2020

author name string

Erin E West

1

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1 March 2020

Hyun-Tak Jin

2

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1 March 2020

Ata-Ur Rasheed

3

1 reference

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1 March 2020

Pablo Penaloza-Macmaster

4

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1 March 2020

Wendy G Tan

6

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1 March 2020

Kendall A Smith

9

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1 March 2020

language of work or name

English

0 references

publication date

15 May 2013

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Journal of Clinical Investigation

1 March 2020

published in

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1 March 2020

volume

123

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1 March 2020

page(s)

2604-2615

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issue

6

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

1 March 2020

cites work

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IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

29 September 2017

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

29 September 2017

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Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

29 September 2017

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Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines

29 September 2017

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The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response

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High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.

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Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

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Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

29 September 2017

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27 June 2018

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IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation

27 June 2018

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27 June 2018

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Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

4 September 2018

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Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients.

4 September 2018

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Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251.

4 September 2018

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Interleukin-2 therapy restores CD8 cell non-cytotoxic anti-HIV responses in primary infection subjects receiving HAART.

4 September 2018

1 reference

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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

4 September 2018

1 reference

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Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy.

4 September 2018

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Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomised controlled trial. ANRS 048 study group.

4 September 2018

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Long-term effects of intermittent interleukin-2 therapy in chronic HIV-infected patients (ANRS 048-079 Trials)

4 September 2018

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12 December 2020

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

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12 December 2020

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

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12 December 2020

Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART

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12 December 2020

Identifiers

DOI

10.1172/JCI67008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23676462%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23676462%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23676462%20AND%20SRC:MED&resulttype=core&format=json