Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance (Q38855681)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21764777%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance (English)

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7 February 2020

5

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7 February 2020

Elena V. Orlova

6

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7 February 2020

author name string

Ricardo Aramayo

1

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7 February 2020

Michael B Sherman

2

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7 February 2020

Kathryne Brownless

3

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7 February 2020

Rudi Lurz

4

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7 February 2020

language of work or name

English

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publication date

14 July 2011

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7 February 2020

published in

Nucleic Acids Research

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7 February 2020

volume

39

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issue

20

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7 February 2020

page(s)

8960-8971

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Creative Commons Attribution-NonCommercial 3.0 Unported

7 February 2020

copyright license

start time

7 November 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes

9 September 2017

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Accurate determination of local defocus and specimen tilt in electron microscopy

9 September 2017

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Decision making by p53: life, death and cancer

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9 September 2017

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Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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p53 oligomerization and DNA looping are linked with transcriptional activation

9 September 2017

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p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

9 September 2017

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Identification of p53 as a sequence-specific DNA-binding protein

9 September 2017

1 reference

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Oncogenic forms of p53 inhibit p53-regulated gene expression

9 September 2017

1 reference

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Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein

9 September 2017

1 reference

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p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

14 September 2017

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The N terminus of p53 regulates its dissociation from DNA.

14 September 2017

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Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

17 June 2018

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How p53 binds DNA as a tetramer

17 June 2018

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17 June 2018

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Structural basis of DNA recognition by p53 tetramers.

22 August 2018

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p53 linear diffusion along DNA requires its C terminus

22 August 2018

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

22 August 2018

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22 August 2018

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Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopy

22 August 2018

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A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene

4 November 2018

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A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

2 December 2018

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12 December 2020

Synergistic transcriptional activation of the MCK promoter by p53: tetramers link separated DNA response elements by DNA looping

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12 December 2020

The wrapping phenomenon in air-dried and negatively stained preparations

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12 December 2020

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

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12 December 2020

Identifiers

DOI

10.1093/NAR/GKR386

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21764777%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21764777%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference