Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies (Q38826744)

6 September 2017

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title

Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies (English)

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6 September 2017

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1

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PubMed ID

27572805

6 September 2017

language of work or name

English

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publication date

30 August 2016

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Expert Opinion on Biological Therapy

6 September 2017

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6 September 2017

16

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6 September 2017

12

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6 September 2017

1455-1468

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Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: a literature-based meta-analysis from 91 trials

6 September 2017

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Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment.

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Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle

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Targeted delivery of protein and gene medicines through the blood-brain barrier

21 January 2018

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Receptor-mediated peptide transport through the blood-brain barrier

21 January 2018

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Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

21 January 2018

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Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier

21 January 2018

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Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease

21 January 2018

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Establishment and Dysfunction of the Blood-Brain Barrier

21 January 2018

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A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain

21 January 2018

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The APOE ɛ4/ɛ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients

21 January 2018

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Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.

21 January 2018

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Serum protein leakage in Alzheimer's disease revisited.

21 January 2018

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MRI measurement of blood-brain barrier permeability following spontaneous reperfusion in the starch microsphere model of ischemia.

21 January 2018

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Blood-brain barrier breakdown in the aging human hippocampus

21 January 2018

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Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease.

21 January 2018

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Examination of blood-brain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography

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Association of Cerebral Microbleeds With Cognitive Decline and Dementia

21 January 2018

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Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier

21 January 2018

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Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits

21 January 2018

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Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues.

21 January 2018

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Blood-brain barrier transcytosis of insulin in developing rabbits

21 January 2018

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Receptor-mediated transcytosis of transferrin across the blood-brain barrier

21 January 2018

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Human blood-brain barrier transferrin receptor

21 January 2018

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Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

21 January 2018

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Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

21 January 2018

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Selective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies

21 January 2018

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Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor

21 January 2018

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Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier

21 January 2018

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Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects.

21 January 2018

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Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice

21 January 2018

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Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset.

21 January 2018

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Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins

21 January 2018

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The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges

21 January 2018

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Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

21 January 2018

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LRP-1-mediated intracellular antibody delivery to the Central Nervous System

21 January 2018

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Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier

21 January 2018

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Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2.

21 January 2018

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LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model

21 January 2018

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Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium

21 January 2018

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A novel platform for engineering blood-brain barrier-crossing bispecific biologics

21 January 2018

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Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.

21 January 2018

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Multiplexed evaluation of serum and CSF pharmacokinetics of brain-targeting single-domain antibodies using a NanoLC-SRM-ILIS method

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The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.

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Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

21 January 2018

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Selective expression of the large neutral amino acid transporter at the blood-brain barrier

21 January 2018

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Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

21 January 2018

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The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane

21 January 2018

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Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer

21 January 2018

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A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier

21 January 2018

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Crystal structure of the human glucose transporter GLUT1

21 January 2018

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GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

21 January 2018

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Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

21 January 2018

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Mfsd2a-based pharmacological strategies for drug delivery across the blood-brain barrier.

21 January 2018

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A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

21 January 2018

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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

21 January 2018

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CSF, blood-brain barrier, and brain drug delivery

21 January 2018

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Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models

21 January 2018

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Amyloid-directed monoclonal antibodies for the treatment of Alzheimer's disease: the point of no return?

21 January 2018

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Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice.

21 January 2018

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Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor

21 January 2018

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Benzodiazepine concentrations in brain directly reflect receptor occupancy: studies of diazepam, lorazepam, and oxazepam

21 January 2018

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Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice

21 January 2018

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Recombinant approaches to IgG-like bispecific antibodies

21 January 2018

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Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

21 January 2018

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Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle

21 January 2018

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Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

21 January 2018

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Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation

21 January 2018

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Design and production of novel tetravalent bispecific antibodies

21 January 2018

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Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

21 January 2018

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Rapid transferrin efflux from brain to blood across the blood-brain barrier

21 January 2018

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Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier

21 January 2018

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Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

21 January 2018

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Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide

21 January 2018

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IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

21 January 2018

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Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein

21 January 2018

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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

21 January 2018

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Metabotropic glutamate receptor 1 mediates the electrophysiological and toxic actions of the cycad derivative beta-N-Methylamino-L-alanine on substantia nigra pars compacta DAergic neurons.

21 January 2018

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21 January 2018

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Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

21 January 2018

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In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)

21 January 2018

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Aberrant insulin signaling in Alzheimer's disease: current knowledge

21 January 2018

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Transferrin receptors in the normal human hippocampus and in Alzheimer's disease.

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A single ascending dose study of bapineuzumab in patients with Alzheimer disease

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Etanercept, improved dosage schedules and combinations in the treatment of psoriasis: an update

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21 January 2018

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Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption

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West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice

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Drug transport across the blood-brain barrier

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10.1080/14712598.2016.1230195

21 January 2018

Identifiers

DOI

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Fatcat

https://api.fatcat.wiki/v0/release/xwg75t2fyzhilcqgj3bpyu2vtq

mapped directly with Wikidata item

30 July 2022

based on heuristic

Fatcat ID

release_xwg75t2fyzhilcqgj3bpyu2vtq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xwg75t2fyzhilcqgj3bpyu2vtq

mapped directly with Wikidata item

30 July 2022

based on heuristic

1 reference

https://api.fatcat.wiki/v0/release/xwg75t2fyzhilcqgj3bpyu2vtq