Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery (Q35621061)

9 August 2017

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title

Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery (English)

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9 August 2017

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1

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PubMed ID

25936389

9 August 2017

language of work or name

English

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publication date

2 May 2015

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Expert Opinion on Therapeutic Targets

9 August 2017

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9 August 2017

19

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9 August 2017

8

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9 August 2017

1059-1072

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The blood-brain barrier: bottleneck in brain drug development

9 August 2017

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A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

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Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

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Blood-brain barrier permeation: molecular parameters governing passive diffusion

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The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

21 January 2018

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Transport of gabapentin by LAT1 (SLC7A5).

21 January 2018

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The ABCs of membrane transporters in health and disease (SLC series): introduction

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

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Differential expression of alpha-actin mRNA and immunoreactive protein in brain microvascular pericytes and smooth muscle cells

21 January 2018

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Human brain microvascular DR-antigen

21 January 2018

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P-Glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries.

21 January 2018

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Differential expression of 53- and 45-kDa brain capillary-specific proteins by brain capillary endothelium and choroid plexus in vivo and by brain capillary endothelium in tissue culture

21 January 2018

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P-glycoprotein and caveolin-1alpha in endothelium and astrocytes of primate brain.

21 January 2018

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Glut1 glucose transporter activity in human brain injury.

21 January 2018

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Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models

21 January 2018

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Developmental modulation of blood-brain barrier and choroid plexus GLUT1 glucose transporter messenger ribonucleic acid and immunoreactive protein in rabbits.

21 January 2018

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Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset.

21 January 2018

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Kinetics of blood-brain transport of hexoses

21 January 2018

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Kinetics of transport and phosphorylation of 2-fluoro-2-deoxy-D-glucose in rat brain.

21 January 2018

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Effects of some chlorinated sugar derivatives on the hexose transport system of the blood/brain barrier

21 January 2018

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Permeability changes in the blood-brain barrier: causes and consequences

21 January 2018

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Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats

21 January 2018

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Monocarboxylic acid transport

21 January 2018

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CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

21 January 2018

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Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.

21 January 2018

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Kinetic analysis of blood-brain barrier transport of amino acids

21 January 2018

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Transport of metabolic substrates through the blood-brain barrier.

21 January 2018

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Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier.

21 January 2018

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Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)

21 January 2018

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Selective expression of the large neutral amino acid transporter at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1042364

Kinetics of neutral amino acid transport across the blood-brain barrier.

21 January 2018

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Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier.

21 January 2018

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pH dependence of histidine affinity for blood-brain barrier carrier transport systems for neutral and cationic amino acids.

21 January 2018

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Carrier mediated blood-brain barrier transport of choline and certain choline analogs.

21 January 2018

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The ubiquitous choline transporter SLC44A1.

21 January 2018

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Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier

21 January 2018

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In vivo evidence for the efflux transport of pentazocine from the brain across the blood-brain barrier using the brain efflux index method

21 January 2018

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Independent blood-brain barrier transport systems for nucleic acid precursors

21 January 2018

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Uptake of adenosine by isolated rat brain capillaries.

21 January 2018

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Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family

21 January 2018

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Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters

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Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

21 January 2018

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Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine

21 January 2018

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Blood-brain barrier genomics and cloning of a novel organic anion transporter

21 January 2018

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Carrier-Mediated Transport of Thyroid Hormones through the Rat Blood-Brain Barrier: Primary Role of Albumin-Bound Hormone*

21 January 2018

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Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

21 January 2018

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Recent advances in blood-brain barrier transport

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Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.

21 January 2018

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Blood—Brain Barrier Genomics

21 January 2018

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Drug transport across the blood-brain barrier

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10.1517/14728222.2015.1042364

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

25936389