The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease. (Q38779167)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26939933%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease (English)

1 reference

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9 March 2020

0 references

1 reference

1

1 reference

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9 March 2020

Francesca la Rosa

2

1 reference

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9 March 2020

Federica Piancone

3

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9 March 2020

Ivana Marventano

5

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9 March 2020

Roberta Mancuso

9

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9 March 2020

author name string

Martina Zoppis

4

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9 March 2020

Elena Calabrese

6

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9 March 2020

Veronica Rainone

7

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9 March 2020

Raffaello Nemni

8

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9 March 2020

Mario Clerici

10

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9 March 2020

publication date

3 March 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26939933%20AND%20SRC:MED&resulttype=core&format=json

Molecular Neurodegeneration

9 March 2020

published in

1 reference

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9 March 2020

volume

11

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9 March 2020

page(s)

23

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describes a project that uses

9 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4778358/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Neuroinflammation in Alzheimer's disease

1 reference

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Innate immunity in Alzheimer's disease

6 September 2017

1 reference

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Novel roles for caspase-8 in IL-1β and inflammasome regulation

6 September 2017

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Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

6 September 2017

1 reference

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Innate immune activation in neurodegenerative disease

6 September 2017

1 reference

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Mechanisms and functions of inflammasomes

6 September 2017

1 reference

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Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis

6 September 2017

1 reference

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FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

6 September 2017

1 reference

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Mechanisms of NOD-like receptor-associated inflammasome activation

6 September 2017

1 reference

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Comparison the effects of two monocyte isolation methods, plastic adherence and magnetic activated cell sorting methods, on phagocytic activity of generated dendritic cells.

6 September 2017

1 reference

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The NLRP3 inflammasome in Alzheimer's disease

6 September 2017

1 reference

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Requirements for innate immune pathways in environmentally induced autoimmunity

6 September 2017

1 reference

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Specific inflammasomes in complex diseases

6 September 2017

1 reference

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Uromodulin triggers IL-1β-dependent innate immunity via the NLRP3 inflammasome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Redox control of NLRP3 inflammasome activation in health and disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Intracellular sensing of microbes and danger signals by the inflammasomes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Interleukin-18, from neuroinflammation to Alzheimer's disease.

6 September 2017

1 reference

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Molecular mechanism of NLRP3 inflammasome activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

The role of microglia in amyloid clearance from the AD brain

6 September 2017

1 reference

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6 September 2017

1 reference

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Inflammation, microglia, and Alzheimer's disease

6 September 2017

1 reference

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Molecular mechanisms involved in inflammasome activation

6 September 2017

1 reference

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CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

6 September 2017

1 reference

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The inflammasomes: guardians of the body

6 September 2017

1 reference

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Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease

6 September 2017

1 reference

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Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Pro-inflammatory cytokines and their effects in the dentate gyrus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

A guided tour into subcellular colocalization analysis in light microscopy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Interleukin-1 mediates Alzheimer and Lewy body pathologies.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Cryopyrin activates the inflammasome in response to toxins and ATP

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Gout-associated uric acid crystals activate the NALP3 inflammasome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Mild cognitive impairment as a diagnostic entity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

TM4: a free, open-source system for microarray data management and analysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

A complex proinflammatory role for peripheral monocytes in Alzheimer's disease.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Silencing of the P2X(7) receptor enhances amyloid-β phagocytosis by microglia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Increased expression of interleukin-18 receptor in blood cells of subjects with mild cognitive impairment and Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

NALP1/NLRP1 genetic variants are associated with Alzheimer disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Emerging inflammasome effector mechanisms

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer's disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Colocalization of fluorescent markers in confocal microscope images of plant cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Lymphocyte subset patterns and cytokine production in Alzheimer's disease patients.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

A new clinical scale for the staging of dementia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4778358

Admission criteria for immunogerontological studies in man: the SENIEUR protocol

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26939933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26939933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S13024-016-0088-1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26939933%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26939933%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

26939933

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26939933%20AND%20SRC:MED&resulttype=core&format=json