Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis (Q38776013)

6 September 2017

Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis (English)

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6 September 2017

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Michelle M Angrish

1

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6 September 2017

Jonathan Phillip Kaiser

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2

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6 September 2017

Charlene A McQueen

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3

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6 September 2017

Brian N Chorley

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4

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6 September 2017

language of work or name

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15 March 2016

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6 September 2017

Toxicological Sciences

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6 September 2017

150

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6 September 2017

2

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6 September 2017

261-268

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Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents

6 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPAR γ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Toxicant-associated steatohepatitis in vinyl chloride workers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Current understanding of fatty acid biosynthesis and the acyl carrier protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Assembly and secretion of hepatic very-low-density lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Synthesis and function of hepatic very-low-density lipoprotein

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Gene expression in human NAFLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Endocrine disrupters as obesogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Minireview: the case for obesogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Natural modulators of liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

The roles of nuclear receptors CAR and PXR in hepatic energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Regulation of hepatic lipogenesis by the transcription factor XBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

The nuclear receptor LXR is a glucose sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Regulation of stearoyl-CoA desaturases and role in metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Nonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Peroxisome proliferator-activated receptor alpha target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Fatty liver and lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Adverse outcome pathway (AOP) development I: strategies and principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Adverse outcome pathway development II: best practices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Toxicant-associated steatohepatitis

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

Liver X receptor in cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW018

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFW018

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6 September 2017

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