Impairments in Motor Neurons, Interneurons and Astrocytes Contribute to Hyperexcitability in ALS: Underlying Mechanisms and Paths to Therapy (Q38761708)

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scientific article published on 3 February 2017

Language	Label	Description	Also known as
English	Impairments in Motor Neurons, Interneurons and Astrocytes Contribute to Hyperexcitability in ALS: Underlying Mechanisms and Paths to Therapy	scientific article published on 3 February 2017

Statements

scholarly article

1 reference

Europe PubMed Central

6 September 2017

Impairments in Motor Neurons, Interneurons and Astrocytes Contribute to Hyperexcitability in ALS: Underlying Mechanisms and Paths to Therapy (English)

1 reference

Europe PubMed Central

6 September 2017

amyotrophic lateral sclerosis

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based on heuristic

inferred from title

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based on heuristic

inferred from title

object named as

Yossi Buskila

2

0 references

object named as

Lezanne Ooi

3

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author name string

Dzung Do-Ha

1

1 reference

Europe PubMed Central

6 September 2017

publication date

3 February 2017

1 reference

Europe PubMed Central

6 September 2017

Molecular Neurobiology

1 reference

Europe PubMed Central

6 September 2017

https://scigraph.springernature.com/pub.10.1007/s12035-017-0392-y

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Changes in sizes of cortical and lower motor neurons in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Incidence of amyotrophic lateral sclerosis in Europe

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

ISIS Survey: an international study on the diagnostic process and its implications in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Genetics of amyotrophic lateral sclerosis: an update.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

State of play in amyotrophic lateral sclerosis genetics

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

The changing scene of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

The puzzling case of hyperexcitability in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Pathophysiological insights into ALS with C9ORF72 expansions.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Corticomotor threshold is reduced in early sporadic amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Fasciculation potentials and earliest changes in motor unit physiology in ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Electrodiagnostic criteria for diagnosis of ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Corticocortical inhibition in human motor cortex

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Transcranial magnetic stimulation: a neuroscientific probe of cortical function in schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Axonal excitability properties in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Latent addition in motor and sensory fibres of human peripheral nerve.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Threshold tracking techniques in the study of human peripheral nerve

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Strength-duration properties of sensory and motor axons in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Effects of short interval intracortical inhibition and intracortical facilitation on short interval intracortical facilitation in human primary motor cortex.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

The wobbler mouse, an ALS animal model

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Reduced GABAergic inhibition explains cortical hyperexcitability in the wobbler mouse model of ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Distribution of GABAAReceptor mRNA in the Motor Cortex of ALS Patients

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Upregulation of persistent sodium conductances in familial ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: An immunohistochemical study

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

The pharmacology and mechanism of action of riluzole

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Potassium buffering in the central nervous system

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10).

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1(G93A) rat model

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Is hyperexcitability really guilty in amyotrophic lateral sclerosis?

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

A single blind randomized controlled clinical trial of mexiletine in amyotrophic lateral sclerosis: Efficacy and safety of sodium channel blocker phase II trial.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Extramotor involvement in ALS: PET studies with the GABAA ligand [11C]flumazenil

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0392-Y

21 January 2018

Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28160214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal ion channel dysfunction in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28160214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The split hand in ALS has a cortical basis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28160214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28160214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/28160214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28160214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12035-017-0392-Y

1 reference

Europe PubMed Central

6 September 2017

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0 references

1 reference

Europe PubMed Central

6 September 2017

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