Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS. (Q48612819)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27249331%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

title

Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27249331%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

3 April 2020

main subject

1 reference

4

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3 April 2020

Steve Vucic

7

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3 April 2020

author name string

Nimeshan Geevasinga

1

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3 April 2020

Parvathi Menon

2

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3 April 2020

Karl Ng

3

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3 April 2020

Karen Byth

5

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3 April 2020

Matthew C Kiernan

6

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publication date

1 June 2016

1 reference

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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

3 April 2020

published in

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3 April 2020

volume

17

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3 April 2020

issue

7-8

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3 April 2020

page(s)

580-588

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Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

3 April 2020

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Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes

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Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes).

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Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron?

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Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease.

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Upregulation of persistent sodium conductances in familial ALS.

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Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis.

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Sensitivity and specificity of threshold tracking transcranial magnetic stimulation for diagnosis of amyotrophic lateral sclerosis: a prospective study.

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Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis.

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Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

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Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells

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General mechanisms of axonal damage and its prevention

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Excitability of human axons

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Electrodiagnostic criteria for diagnosis of ALS.

21 January 2018

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The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III).

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Assessment of cortical excitability using threshold tracking techniques

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Two phases of intracortical inhibition revealed by transcranial magnetic threshold tracking.

21 January 2018

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Magnetic brain stimulation: the silent period after the motor evoked potential.

21 January 2018

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Electrical stimulation over the human vertebral column: which neural elements are excited?

21 January 2018

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Riluzole suppresses motor cortex facilitation in correlation to its plasma level. A study using transcranial magnetic stimulation.

21 January 2018

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Influence of the N-methyl-D-aspartate antagonist memantine on human motor cortex excitability.

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Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights

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Cortical thickness in ALS: towards a marker for upper motor neuron involvement.

21 January 2018

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Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral Sclerosis

21 January 2018

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Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis

21 January 2018

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Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes

21 January 2018

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21 January 2018

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Cortical excitability distinguishes ALS from mimic disorders.

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Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis.

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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21 January 2018

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Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

21 January 2018

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21 January 2018

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p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

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21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27249331%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference