Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers (Q38752201)

2 July 2018

title

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers (English)

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2 July 2018

genome-wide association study

main subject

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38

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2 July 2018

Alison Goate

45

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2 July 2018

Yuetiva Deming

Yuetiva Deming

1

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Henrik Zetterberg

28

Henrik Zetterberg

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33

John Q Trojanowski

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27

Kaj Blennow

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17

David M Holtzman

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John Budde

10

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Richard Mayeux

36

Richard Mayeux

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29

Lennart Minthon

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PMCID

5613285

Alzheimer's Disease Neuroimaging Initiative

2 July 2018

42

Alzheimer’s Disease Neuroimaging Initiative (ADNI)

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19

Sungeun Kim

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22

Marilyn Albert

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18

John C Morris

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16

Anne M Fagan

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26

Ronald C Petersen

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35

Jonathan L Haines

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21

Philip L De Jager

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Leslie M. Shaw

32

Leslie M Shaw

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John S K Kauwe

44

John S K Kauwe

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2 July 2018

Jorge L Del-Aguila

5

Jorge L Del-Aguila

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2 July 2018

Oscar Harari

4

Oscar Harari

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2 July 2018

Yefei Cai

8

Yefei Cai

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David S Carrell

7

David Carrell

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Sarah Bertelsen

15

Sarah Bertelsen

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2 July 2018

Vivianna M Van Deerlin

30

Vivianna M Van Deerlin

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Elaine Peskind

39

Elaine R Peskind

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Alzheimer's Disease Genetics Consortium (ADGC)

43

Alzheimer Disease Genetic Consortium (ADGC)

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2 July 2018

Abhay Moghekar

23

Abhay Moghekar

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Gerard D Schellenberg

34

Gerard Schellenberg

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Manav Kapoor

3

Manav Kapoor

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Antonio F Di Narzo

41

Antonio F Di Narzo

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2 July 2018

Benjamin Saef

12

Benjamin Saef

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2 July 2018

Kuan-Lin Huang

14

Kuan-Lin Huang

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2 July 2018

Virginia Man-Yee Lee

31

Virginia Man-Yee Lee

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2 July 2018

Maria Victoria Fernandez

9

Maria Victoria Fernandez

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2 July 2018

Matthias Riemenschneider

25

Matthias Riemenschneider

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2 July 2018

author name string

Zeran Li

2

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Kathleen Black

6

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Shengmei Ma

11

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Bill Howells

13

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Richard O'Brien

24

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Ge Li

40

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2 July 2018

language of work or name

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28 February 2017

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2 July 2018

published in

Acta Neuropathologica

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2 July 2018

volume

133

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2 July 2018

page(s)

839-856

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2 July 2018

issue

5

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2 July 2018

describes a project that uses

genome-wide association study

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based on heuristic

inferred from title

exact match

https://scigraph.springernature.com/pub.10.1007/s00401-017-1685-y

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cites work

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3 July 2018

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Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases

3 July 2018

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3 July 2018

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3 July 2018

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3 July 2018

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3 July 2018

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3 July 2018

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Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

3 July 2018

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

3 July 2018

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Systematic identification of trans eQTLs as putative drivers of known disease associations

3 July 2018

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3 July 2018

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3 July 2018

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3 July 2018

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3 July 2018

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TREM2 is associated with the risk of Alzheimer's disease in Spanish population

3 July 2018

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TREM2 Variants in Alzheimer's Disease

3 July 2018

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

3 July 2018

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A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation

3 July 2018

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3 July 2018

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Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

3 July 2018

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3 July 2018

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3 July 2018

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The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects

3 July 2018

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HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

3 July 2018

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Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies

3 July 2018

1 reference

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

3 July 2018

1 reference

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

3 July 2018

1 reference

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Global analysis of the impact of environmental perturbation on cis-regulation of gene expression

3 July 2018

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GCTA: a tool for genome-wide complex trait analysis

3 July 2018

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Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort

3 July 2018

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Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study

3 July 2018

1 reference

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SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease

3 July 2018

1 reference

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Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people

3 July 2018

1 reference

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Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment

3 July 2018

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Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels

3 July 2018

1 reference

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LocusZoom: regional visualization of genome-wide association scan results

3 July 2018

1 reference

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METAL: fast and efficient meta-analysis of genomewide association scans

3 July 2018

1 reference

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ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

3 July 2018

1 reference

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Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database

3 July 2018

1 reference

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GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication

3 July 2018

1 reference

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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

3 July 2018

1 reference

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

3 July 2018

1 reference

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Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

3 July 2018

1 reference

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Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly

3 July 2018

1 reference

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Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study.

3 July 2018

1 reference

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Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults

3 July 2018

1 reference

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Principal components analysis corrects for stratification in genome-wide association studies

3 July 2018

1 reference

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Role of Genes and Environments for Explaining Alzheimer Disease

3 July 2018

1 reference

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Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

3 July 2018

1 reference

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MRI and CSF studies in the early diagnosis of Alzheimer's disease

3 July 2018

1 reference

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Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Increasing CSF phospho-tau levels during cognitive decline and progression to dementia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Neuropathological and neuropsychological changes in "normal" aging: evidence for preclinical Alzheimer disease in cognitively normal individuals.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5613285

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00401-017-1685-Y

The roles of inflammation and immune mechanisms in Alzheimer's disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00401-017-1685-Y

Analysis of shared heritability in common disorders of the brain

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00401-017-1685-Y

10.1007/S00401-017-1685-Y

21 January 2018

Identifiers

DOI

1 reference

2 July 2018

Dimensions Publication ID

0 references

1 reference

2 July 2018

PubMed ID

28247064

1 reference

2 July 2018