Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein (Q38675786)

5 September 2017

Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein (English)

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5 September 2017

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nucleoprotein [SARS-Cov]

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author name string

Chung-ke Chang

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5 September 2017

Shou-Chen Lo

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5 September 2017

Yong-Sheng Wang

3

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5 September 2017

Ming-Hon Hou

4

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5 September 2017

language of work or name

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12 December 2015

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5 September 2017

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5 September 2017

21

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5 September 2017

4

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5 September 2017

562-572

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Two-year prospective study of single infections and co-infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease.

5 September 2017

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Coronavirus infections in hospitalized pediatric patients with acute respiratory tract disease

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Detection of the human coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata, Japan

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Coronavirus HKU1 and other coronavirus infections in Hong Kong

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Detection of human coronavirus NL63 and OC43 in children with acute respiratory infections in Niigata, Japan, between 2010 and 2011

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The pediatric burden of human coronaviruses evaluated for twenty years

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The dominance of human coronavirus OC43 and NL63 infections in infants

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Epidemiology of respiratory viral infection using multiplex rt-PCR in Cheonan, Korea (2006-2010).

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Human coronavirus infections in rural Thailand: a comprehensive study using real-time reverse-transcription polymerase chain reaction assays

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Human coronavirus in young children hospitalized for acute respiratory illness and asymptomatic controls

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Epidemiological and clinical features of human coronavirus infections among different subsets of patients

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Characterization of human coronavirus etiology in Chinese adults with acute upper respiratory tract infection by real-time RT-PCR assays

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

High incidence but low burden of coronaviruses and preferential associations between respiratory viruses.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The novel human coronaviruses NL63 and HKU1.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Croup is associated with the novel coronavirus NL63

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Middle East respiratory syndrome.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The Middle East respiratory syndrome--how worried should we be?

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Bats are natural reservoirs of SARS-like coronaviruses

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

MERS coronaviruses in dromedary camels, Egypt.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

MERS coronavirus in dromedary camel herd, Saudi Arabia

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Human respiratory coronavirus OC43: genetic stability and neuroinvasion

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

SARS--beginning to understand a new virus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Structure and function studies of the nucleocapsid protein of mouse hepatitis virus

16 April 2021

2 references

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

16 April 2021

12 December 2020

The nucleoprotein is required for efficient coronavirus genome replication.

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Selective replication of coronavirus genomes that express nucleocapsid protein

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Coronavirus nucleocapsid protein facilitates template switching and is required for efficient transcription

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Serological responses in patients with severe acute respiratory syndrome coronavirus infection and cross-reactivity with human coronaviruses 229E, OC43, and NL63.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Baculovirus expression of HCoV-OC43 nucleocapsid protein and development of a Western blot assay for detection of human antibodies against HCoV-OC43.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Structural Basis for the Identification of the N-Terminal Domain of Coronavirus Nucleocapsid Protein as an Antiviral Target

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Influenza virus nucleoprotein: structure, RNA binding, oligomerization and antiviral drug target.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The HIV-1 nucleocapsid zinc finger protein as a target of antiretroviral therapy

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Modular organization of SARS coronavirus nucleocapsid protein.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The SARS coronavirus nucleocapsid protein--forms and functions.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Carboxyl terminus of severe acute respiratory syndrome coronavirus nucleocapsid protein: self-association analysis and nucleic acid binding characterization

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid protein packaging.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Elucidation of the stability and functional regions of the human coronavirus OC43 nucleocapsid protein

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Coronavirus-like particles present in simian faeces

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Ribonucleoprotein of Avian Infectious Bronchitis Virus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

The genome of human coronavirus strain 229E

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Cryo-electron tomography of mouse hepatitis virus: Insights into the structure of the coronavirion.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Roles of intrinsic disorder in protein-nucleic acid interactions

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Are weak protein–protein interactions the general rule in capsid assembly?

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Recognition of the murine coronavirus genomic RNA packaging signal depends on the second RNA-binding domain of the nucleocapsid protein

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Viral and cellular RNA helicases as antiviral targets

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Influenza nucleoprotein: promising target for antiviral chemotherapy.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Induction of SARS-nucleoprotein-specific immune response by use of DNA vaccine

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Vaccination of mice with recombinant baculovirus expressing spike or nucleocapsid protein of SARS-like coronavirus generates humoral and cellular immune responses

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Induction of neutralising antibodies and cellular immune responses against SARS coronavirus by recombinant measles viruses

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Induction of T-cell response by a DNA vaccine encoding a novel HLA-A*0201 severe acute respiratory syndrome coronavirus epitope

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg).

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Antiviral drugs specific for coronaviruses in preclinical development

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

A decade after SARS: strategies for controlling emerging coronaviruses

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Identification of cavities on protein surface using multiple computational approaches for drug binding site prediction.

16 April 2021

1 reference

https://api.crossref.org/works/10.1016/J.DRUDIS.2015.11.015

Background Paper Functions of the Coronavirus Nucleocapsid Protein

16 April 2021

1 reference

12 December 2020

In vitro replication of mouse hepatitis virus strain A59

1 reference

12 December 2020

Inhibition of parvovirus minute virus of mice replication by a peptide involved in the oligomerization of nonstructural protein NS1.

1 reference

12 December 2020

National Ambulatory Medical Care Survey: 2006 summary.

1 reference

12 December 2020

Human coronaviruses: what do they cause?

1 reference

12 December 2020

Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein

1 reference

12 December 2020

National Ambulatory Medical Care Survey: 2007 summary.

1 reference

12 December 2020

10.1016/J.DRUDIS.2015.11.015

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DOI

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5 September 2017

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