FOXO transcription factors in cancer development and therapy (Q38674456)

5 September 2017

FOXO transcription factors in cancer development and therapy (English)

1 reference

5 September 2017

Jean-Baptiste Demoulin

series ordinal

2

1 reference

5 September 2017

Alexandra Coomans de Brachène

series ordinal

1

1 reference

5 September 2017

19 December 2015

1 reference

Cellular and Molecular Life Sciences

5 September 2017

1 reference

5 September 2017

73

1 reference

5 September 2017

1159-1172

1 reference

5 September 2017

6

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-015-2112-y

5 September 2017

0 references

cites work

FOXOs, cancer and regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The extending network of FOXO transcriptional target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Down Regulation of FOXO1 Promotes Cell Proliferation in Cervical Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Unregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Upregulation of MircoRNA-370 induces proliferation in human prostate cancer cells by downregulating the transcription factor FOXO1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

MicroRNA-1269 promotes proliferation in human hepatocellular carcinoma via downregulation of FOXO1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Many forks in the path: cycling with FoxO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT signal pathway in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

A negative feedback signaling network underlies oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

PAX3-FOXO1 fusion gene in rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Common mechanism for oncogenic activation of MLL by forkhead family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Analysis of FOXO1 mutations in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Deciphering the role of forkhead transcription factors in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Resistance to paclitaxel is proportional to cellular total antioxidant capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

The involvement of FOXO1 in cytotoxic stress and drug-resistance induced by paclitaxel in ovarian cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

FoxO3a and nilotinib-induced erythroid differentiation of CML-BC cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2112-Y

AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily

21 January 2018

1 reference

12 December 2020

FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas.

1 reference

12 December 2020

miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1.

1 reference

12 December 2020

FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity.

1 reference

12 December 2020

Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.

1 reference

12 December 2020

FOXO3 is inhibited by oncogenic PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide

1 reference

12 December 2020

Involvement of post-transcriptional regulation of FOXO1 by HuR in 5-FU-induced apoptosis in breast cancer cells

1 reference

12 December 2020

Angiogenesis and its therapeutic opportunities

1 reference

12 December 2020

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation

1 reference

12 December 2020

miR-96 regulates FOXO1-mediated cell apoptosis in bladder cancer

1 reference

12 December 2020

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma

1 reference

12 December 2020

FOXO transcription factors: their clinical significance and regulation.

1 reference

12 December 2020

FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway

1 reference

12 December 2020

MiR-135b promotes proliferation and invasion of osteosarcoma cells via targeting FOXO1.

1 reference

12 December 2020

A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma

1 reference

12 December 2020

10.1007/S00018-015-2112-Y

Identifiers

DOI

1 reference

5 September 2017

1 reference

PubMed ID

26686861